Kajian pustaka toksisitas tanaman nanas (Ananas comosus [L.] Merr)

Qurratul Aeni; Siti Rahmatul Aini; Iman Surya Pratama

doi:10.29303/sjp.v3i1.164

Kajian pustaka toksisitas tanaman nanas (Ananas comosus [L.] Merr)

Authors

Qurratul Aeni , Siti Rahmatul Aini , Iman Surya Pratama

DOI:

10.29303/sjp.v3i1.164

Published:

2022-04-28

Issue:

Vol. 3 No. 1 (2022): April

Keywords:

Pineapple (Ananas comosus [L.] Merr), toxicity

Articles

Downloads

PDF

How to Cite

Aeni, Q., Aini, S. R., & Pratama, I. S. (2022). Kajian pustaka toksisitas tanaman nanas (Ananas comosus [L.] Merr). Sasambo Journal of Pharmacy, 3(1), 49–62. https://doi.org/10.29303/sjp.v3i1.164

Download Citation

Abstract

Pineapple plants are used ethnomedicinally in various countries, especially in Indonesia. Several studies have shown that pineapple plants have pharmacological effects both in vitro and in vivo on various diseases. Ananas Plant has the potential to be cultivated as medicine products. The toxicity of Ananas comosus (L) Merr important to acknowledge. This literature review aims to provide comprehensive information through a literature review regarding the toxicity of pineapple (Ananas comosus [L.] Merr). The literature review was collected in the period 2010 to 2021 which was obtained from the Google Scholar and Pubmed databases with a total of 9544 and a study was carried out on 10 works of literature. Based on the results of 10 literatures that have met the inclusion criteria, it shows that the in vitro toxicity test on pineapple (Ananas comosus [L.] Merr) has an LC50 of 403.83 to 9000 ppm which belongs to the category of practically non-toxic to moderately toxic. In vivo toxicity test showed that LD50 > 5000 mg/kgBW showed no deaths which were classified as practically non-toxic. From the results of literature research, it can be said that toxic plants (Ananas comosus [L.] Merr) have a toxicity category of practically non-toxic to moderately toxic in vitro studies. The results of the in vivo test showed that there were no deaths in the test animals which were in the category of practically non-toxic to mildly toxic.

References

Aeni, Q. (2022). Penentuan Derajat Ketoksikan Jus Limbah Kulit Nanas (Ananas comosus [L.] Merr) pada Ikan Mas (Cyprinus carpio) [Unpublished master’s thesis]. Universitas Mataram.

Ajayi, A. M., Coker, A. I., Oyebanjo, O. T., Adebanjo, I. M., & Ademowo, O. G. (2022). Ananas comosus (L) Merrill (pineapple) fruit peel extract demonstrates antimalarial, anti-nociceptive and anti-inflammatory activities in experimental models. Journal of Ethnopharmacology, 282, 114576. https://doi.org/10.1016/j.jep.2021.114576

Akram, M., Hamid, A., Ahmed, K., Ghaffa, A., Naveed, T., & Ahmed, S. (2013). Hypocholestrolemic activity of plants: a review. International Journal of Agronomy and Plant Production, 4(11), 2906-11. http:// www.ijappjournal.com

Asase, A., Akwetey, G. A., & Achel, D. G. (2010). Ethnopharmacological use of herbal remedies for the treatment of malaria in the Dangme West District of Ghana. Journal of ethnopharmacology, 129(3), 367-376. https://doi.org/10.1016/j.jep.2010.04.001

Asif, M. (2012). A brief study of toxic effects of some medicinal herbs on kidney. Advanced biomedical research, 1.

Badan Pengawas Obat dan Makanan. (2014). Pedoman Uji Toksisitas Nonklinik secara In Vivo. Badan Pengawas Obat dan Makanan RI. https://jdih.pom.go.id/download/product/701/13/2014

Badan Pengawas Obat dan Makanan (2005). Standarisasi Ekstrak Tumbuhan Obat Indonesia, Salah Satu Tahapan Penting Dalam Pengembangan Obat Indonesia. Badan Pengawas Obat Dan Makanan RI.

Badan Pusat Statistik. (2015). https://www.bps.go.id/indicator/55/62/1/produksi-tanaman-buah-buahan.html

Cormanes, J. M. Y., Portugaliza, H. P., & Quilicot, A. M. M. (2016). In vivo anthelmintic activity of pineapple (Ananas comosus Merr.) fruit peeling juice in semi-scavenging Philippine native chicken naturally co-infected with Ascaridia galli and Heterakis gallinarum. Livest. Res. Rural Dev, 28(5), 82. http://www.lrrd.org/lrrd28/5/corm28082.html

Cornelia, M., & Kristyanti, T. (2021). Utilization of Pineapple’s (Ananas comosus L. Merr) Peel Waste as Raw Material in Cider Making. https://www.scitepress.org/Papers/2018/100414/100414.pdf.

Dalimartha, S. (2000). Atlas tumbuhan obat Indonesia Jilid II. Trubus Agriwidya.

Dalimartha, S. (2007). Atlas Tumbuhan Indonesia. Pustaka Bunda.

Damiyati, S. Y., Pratama, I. S., & Tresnani, G. (2021). In vitro anthelmintic activity of pineapple peel juice (Ananas comosus (L.) Merr.) against Paramphistomum sp. Communications in Science and Technology, 6(1), 49-54. https://doi.org/10.21924/cst.6.1.2021.394

Debnath, P., Dey, P., Chanda, A., & Bhakta, T. (2012). A Survey on Pineapple and its medicinal value. Scholars Academic Journal of Pharmacy, 1(1), 24-29.

Debnath, B., Singh, W. S., & Manna, K. (2021). A phytopharmacological review on Ananas comosus. Advances in Traditional Medicine, 1-8. https://link.springer.com/article/10.1007/s13596-021-00563-w

Dutta, S., & Bhattacharyya, D. (2013). Enzymatic, antimicrobial and toxicity studies of the aqueous extract of Ananas comosus (pineapple) crown leaf. Journal of Ethnopharmacology, 150(2), 451-457. https://doi.org/10.1016/j.jep.2013.08.024

Erkekoglu, P., Giray, B. K., & Basaran, N. (2011). 3R principle and alternative toxicity testing methods. Fabad J Pharm Sci, 36(1), 101-17. http://dergi.fabad.org.tr/pdf/volum36/issue2/101-117.pdf.

Faisal, M. M., Hossa, F. M. M., Rahman, S., Bashar, A. B. M. A., Hossan, S., & Rahmatullah, M. (2014). Effect of methanolic extract of Ananas comosus Leaves on glucose tolerance and acetic acid induced pain in Swiss albino mice. World J. Pharm. Res, 3(8), 24-34. https://www.academia.edu/download/34967142/ANANAS_COMOSUS.pdf.

Fitriyasti, B., & Salmi, S. (2021). Efek toksisitas ekstrak bromelin buah nanas (Ananas comosus L.) dengan metode Brine Shrimp Lethality Test (BSLT). EKOTONIA: Jurnal Penelitian Biologi, Botani, Zoologi Dan Mikrobiologi, 6(1), 12-16. https://doi.org/10.33019/ekotonia.v6i1.2571

Hassan, A., Othman, Z., & Siriphanich, J. (2011). Pineapple (Ananas comosus L. Merr.). In Postharvest biology and technology of tropical and subtropical fruits (pp. 194-218e). Woodhead Publishing.

Helen, P. M., Teena, D. S., Jacob, J. G., James, J. J., & Anitha, C. (2019). Preliminary Phytochemical Screening and Antioxidant Activity of Leaf, Stem and Fruit Ananas comosus. World J. Pharm. Res, 8(5), 1407-1416. https://wjpr.s3.ap-south 1.amazonaws.com/ article_issue/ 1554362945.pdf.

Hidayat, R.S., dan Napitupulu, R. (Ed.). (2015). Kitab Tumbuhan Obat.

Iyamah, P. C., & Idu, M. (2015). Ethnomedicinal survey of plants used in the treatment of malaria in Southern Nigeria. Journal of ethnopharmacology, 173, 287-302. https://doi.org/10.1016/j.jep.2015.07.008

Jovanović, M., Milutinović, M., Kostić, M., Miladinović, B., Kitić, N., Branković, S., & Kitić, D. (2018). Antioxidant capacity of pineapple (Ananas comosus (L.) Merr.) extracts and juice. Lekovite sirovine, (38), 27-30. http://dx.doi.org/10.5937/leksir1838027J

Kadir, M. F., Sayeed, M. S. B., & Mia, M. M. K. (2012). Ethnopharmacological survey of medicinal plants used by indigenous and tribal people in Rangamati, Bangladesh. Journal of ethnopharmacology, 144(3), 627-637. https://doi.org/10.1016/j.jep.2012.10.003

Kargutkar, S., & Brijesh, S. (2016). Anti-rheumatic activity of Ananas comosus fruit peel extract in a complete Freund’s adjuvant rat model. Pharmaceutical biology, 54(11), 2616-2622. https://doi.org/10.3109/13880209.2016.1173066

Kargutkar, S., & Brijesh, S. (2018). Anti-inflammatory evaluation and characterization of leaf extract of Ananas comosus. Inflammopharmacology, 26(2), 469-477. https://link.springer.com/article/10.1007/s10787-017-0379-3

Lubis, E. R. (2020). Hujan Rezeki Budi Daya Nanas. Bhuana Ilmu Populer.

Mallik, D., Bhattacharjee, C., & Gouda, T. S. (2014). Pharmacological intervention of the fruit of plant Ananas comosus acting as hepatoprotective activity in animal models. Indian Journal of Research in Pharmacy and Biotechnology, 2(3), 1167. https://www.researchgate.net/profile/Chiranjib Bhattacharjee/publication

Mallik, D., Deb, L., Gandhare, B., & Bhattacharjee, C. (2019). Evaluation of Ananas comosus Fruit for Antiulcer Potentials on Experimental Animals. J. Harmon. Res. Appl. Sci, 7, 89.

Martina, M., Oewen, R. R., Riyanti, E.,

Syawqie, A., & Supriatno, S. (2011). The effects of ethyl acetate fraction of Ananas comosus (L.) Merr. of tongue cancer cell growth inhibition Supri’s Clone-1, invitro. Padjadjaran Journal of Dentistry, 23(2). http://jurnal.unpad.ac.id/pjd/article/view/14017.

Medicinal benefits of pineapple plant. Healthscope: The Official Research Book of Faculty of Health Sciences, UiTM, 3(2), 54-59.

Megawati, M. (2020). Phytochemical Screening, Secondary Metabolites and Biological Activities of Southeast Sulawesi Plants. Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta). https://doi.org/10.20956/ica.v13i2.11138

Mohamad, N., Ramli, N., Abd-Aziz, S., & Ibrahim, M. F. (2019). Comparison of hydro-distillation, hydro-distillation with enzyme-assisted and supercritical fluid for the extraction of essential oil from pineapple peels. 3 Biotech, 9(6), 1-9. https://link.springer.com/article/10.1007/s13205-019-1767-8

OECD (2002) Guidelines for the Testing of Chemicals No. 420. Acute Oral Toxicity - Fixed Dose Procedure https://doi.org/10.1787/9789264070943-en.

OECD (2002) Guidelines for the Testing of Chemicals No. 423: Acute Oral toxicity - Acute Toxic Class Method. https://doi.org/10.1787/9789264071001-en

OECD (2002) Guidelines for the Testing of Chemicals No. 425 Acute Oral Toxicity: Up-and-Down Procedure. https://doi.org/10.1787/9789264071049-en

OECD (2008) Guidelines for the Testing of Chemicals No. 4 Repeated Dose 28-day Oral Toxicity Study in Rodents https://doi.org/10.1787/9789264070684-en

Ogose, N., Hirochi, M., Ebata, T., & Katsumata, Y. (2009). Reproduction study in rats treated orally with yacon extracts. Yakuri to Chiryo, 37(6), 511-519. https://link.springer.com/article/10.1007/s13205-019-1767-8

Oktafia, N., Susanti, R., & Purwanti, N. U (2019). Uji Toksisitas Akut Ekstrak Etanol Kulit Buah Nanas (Ananas comosus L.) Terhadap Tikus Putih Betina (Rattus norvegicus L.) Galur Wistar. Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN, 4(1). https://jurnal.untan.ac.id/index.php/jmfarmasi/article/view/45667.

Olorunniyi, O. F., & Morenikeji, O. A. (2013). The extent of use of herbal medicine in malaria management in Ido/Osi local government area of Ekiti state, Nigeria. Journal of Medicinal Plants Research, 7(42), 3171-3178. https://doi.org/10.5897/JMPR2013.5101

Paixão, J., de Araújo Neto, J. F., Oliveira do Nascimento, B., Mota da Costa, D., Neves Brandão, H., Duarte Souza, F. V., ... & de Lima David, J. P. (2021). Pharmacological Actions of Ananas comosus L. Merril: Revision of the Works Published from 1966 to 2020. Pharmacognosy Reviews, 15(29). https://www.phcogrev.com/sites/default/files/PharmacognRev-15-29-57.pdf.

Rahmayanti, V., & Ardiansyah, S. (2019). Kinerja Fungsi Ginjal pada Kelinci (Lepus nigricollins) Diabetes yang diberi Ekstrak Bonggol Buah Nanas (Ananas comusus L.). Medicra (Journal of Medical Laboratory Science/Technology), 2(2), 63-67. https://medicra.umsida.ac.id/index.php/medicra/article/view/1606.

Rahman, I. A., Mohamed, E., Camalxaman, S. N., Haron, N., & Rambely, A. S. (2020). Ananas comosus (L.) Merr.: A mini review of its therapeutic properties. Healthscope: The Official Research Book of Faculty of Health Sciences, 3(2). http://www.healthscopefsk.com/index.php/research/article/view/146

Redaksi AgroMedia (2008). Buku Pintar Tanaman Obat. PT. AgroMedia Pustaka.

Saxena, P., & Panjwani, D. (2014). Cardioprotective potential of hydro-alcoholic fruit extract of Ananas comosus against isoproterenol induced myocardial infraction in Wistar Albino rats. Journal of Acute Disease, 3(3), 228-234. https://doi.org/10.1016/S2221-6189(14)60051-2

Sunarjono, H. (2008). Berkebun 21 Jenis Tanaman Buah. Penebar Swadaya.

Yetein, M. H., Houessou, L. G., Lougbégnon, T. O., Teka, O., & Tente, B. (2013). Ethnobotanical study of medicinal plants used for the treatment of malaria in plateau of Allada, Benin (West Africa). Journal of ethnopharmacology, 146(1), 154-163. https://doi.org/10.1016/j.jep.2012.12.022

Zharfan, R. S., Purwono, P. B., & Mustika, A. (2017). Antimicrobial activity of pineapple (Ananas comosus L. Merr) extract against multidrug-resistant of Pseudomonas aeruginosa: An in vitro study. Indonesian Journal of Tropical and Infectious Disease, 6(5), 118-123. https://e-journal.unair.ac.id/index.php/IJTID/article/viewFile/4159/4049

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with Sasambo Journal of Pharmacy (SJP), agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Lisensi Creative Commons Atribusi 4.0 Internasional. This license allows authors to use all articles, data sets, graphics and appendices in data mining applications, search engines, web sites, blogs, and other platforms by providing an appropriate reference. The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Sasambo Journal of Pharmacy
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

Kajian pustaka toksisitas tanaman nanas (Ananas comosus [L.] Merr)

Authors

DOI:

Published:

Issue:

Keywords:

Articles

Downloads

How to Cite

Abstract

References

License

Current Issue

Information

Developed By

Official Website Of

Jurnal Farmasi, Fakultas Kedokteran, Universitas Mataram

Contact Us

Official link

Share & Follow