Cyclea barbata L. Miers.: Penggunaan tradisional, fitokimia, dan aktivitas farmakologi
DOI:
10.29303/sjp.v3i2.178Downloads
Abstract
Indonesian people still favor the use of traditional medicine because they believe its side effects are lower than synthetic drugs. One of the plants that can be used in traditional medicine is Cyclea barbata L. Miers, or green grass jelly. This study aimed to explain and summarize the traditional use, phytochemical content, and pharmacological activity of C. barbata. All information on C. barbata was collected from various electronic databases (Google Scholar, Science Direct, and PubMed) using important and related keywords. Secondary metabolites found in stems, roots, and leaves are alkaloids and flavonoids. The pharmacological activities of C. barbata include antibacterial, antioxidant, anti-plasmodial, immunomodulator, Alzheimer, anti-inflammatory, anti-cholesterol, and antiulcer. Although C. barbata has been used empirically, further research is still needed to ensure the effectiveness and safety of this plant.
Keywords:
Cyclea barbata, traditional use, phytochemicals, pharmacological activitiesReferences
Adiyaksa, I. K., Zuhud, E. A. M., & Siswoyo. (2020). Conservation strategy of Cuing (Cyclea barbata Miers) in Mount Ciremai National Park as forest fuctional food based on bioecology and utilization rate. IOP Conference Series: Earth and Environmental Science, 528(1). https://doi.org/10.1088/1755-1315/528/1/012011
Ammar, L. A., Kurniawati, B., Anggorowati, D., Putri Cahyaningsih, P. A., & Setyawan, A. D. (2021). Ethnobotanical study of the medicinal plant used by local communities in karst area of Pacitan District, East Java, Indonesia. International Journal of Tropical Drylands, 5(2), 84–93. https://doi.org/10.13057/tropdrylands/t050205
Angerhofer, C. K., Guinaudeau, H., Wongpanich, V., Pezzuto, J. M., & Cordell, G. A. (1999). Antiplasmodial and cytotoxic activity of natural bisbenzylisoquinoline alkaloids. Journal of Natural Products, 62(1), 59–66. https://doi.org/https://doi.org/10.1021/np980144f
Ani, N., Rohyani, I. S., & Ustadz, M. (2018). Pengetahuan masyarakat tentang jenis tumbuhan obat di kawasan Taman Wisata Alam Madapangga Sumbawa. Jurnal Pijar Mipa, 13(2), 160. https://doi.org/10.29303/jpm.v13i2.751
Arkarapanthu, A., Chavasit, V., Sungpuag, P., & Phuphathanaphong, L. (2005). Gel extracted from Khruea-ma-noi (Cyclea barbata Miers) leaves: Chemical composition and gelation properties. Journal of the Science of Food and Agriculture, 85(10), 1741–1749. https://doi.org/10.1002/jsfa.2116
Arrosyid, M., Sutaryono, & Muliana, R. (2019). Uji efektivitas ekstrak etanol daun cincau hijau (Cyclea barbata Miers) terhadap bakteri Staphylococcus aureus. Cerata Jurnal Ilmu Farmasi, 10(2), 45–50. https://ejournal.stikesmukla.ac.id/index.php/cerata/article/view/87
Chalid, S. Y. (2003). Effect of green cincau leaves (Cyclea barbata Miers and Premna oblongiofolia Merr) extracts on antioxidant activity and tumor growth of mammary gland of transplantable mice. Institut Pertanian Bogor.
Elliott, E., Chassagne, F., Aubouy, A., Deharo, E., Souvanasy, O., Sythamala, P., Sydara, K., Lamxay, V., Manithip, C., Torres, J. A., & Bourdy, G. (2020). Forest Fevers: Traditional treatment of malaria in the southern lowlands of Laos. Journal of Ethnopharmacology, 249, 112187. https://doi.org/10.1016/j.jep.2019.112187
Farida, Y., Gangga, E., Kartiningsih, K., & Arsila, A. (2015). Formulation and the antioxidant activity of Cincau hijau leaves (Cyclea barbata L. Miers) ethanolic extract. Jurnal Tumbuhan Obat Indonesia, 8(2), 58–62. https://doi.org/10.22435/jtoi.v8i2.6412.58-62
Gangga, E., Purwati, R., Farida, Y., & Kartiningsih, K. (2017). Determination of quality parameters and antioxidant activity of cincau hijau leaves (Cyclea barbata L. Miers.). Jurnal Ilmu Kefarmasian Indonesia, 15(2), 236–243.
Guinaudeau, H., Lin, L. Z., Ruangrungsi, N., & Cordell, G. A. (1993). Bisbenzylisoquinoline alkaloids from Cyclea barbata. Journal of Natural Products, 56(11), 1989–1992. https://doi.org/https://doi.org/10.1021/np50101a020
Handayani, N. F., Elya, B., & Puspitasari, N. (2018). Cyclea barbata leaf extract: Lipoxygenase inhibitory activity and phytochemical screening. International Journal of Applied Pharmaceutics, 10(Special Issue 1), 106–109. https://doi.org/10.22159/ijap.2018.v10s1.22
Haque, M. M., Choudhury, M. S., Hossain, M. S., Haque, M. A., Seraj, S., & Rahmatullah, M. (2012). Ethnographic information and medicinal formulations of a Mro community of Gazalia union in the Bandarbans district of Bangladesh. American-Eurasian Journal of Sustainable Agriculture, 6(3), 162–171.
Harmayani, E., Anal, A. K., Puripaatanvavong, J., & Bhat, R. (2019). Healthy food traditions of Asia: Exploratory case studies from Indonesia, Thailand, Malaysia, and Nepal. Journal of Ethnic Foods, 6(1). https://doi.org/https://doi.org/10.1186/s42779-019-0002-x
Hossan, S., Hanif, A., Jahan, R., & Rahmatullah, M. (2014). Ethnomedicinal plants of the bawm tribal community of rowangchhari in bandarban district of Bangladesh. Journal of Alternative and Complementary Medicine, 20(8), 581–589. https://doi.org/10.1089/acm.2013.0187
Ismail, D. D. S. ., Ratnawati, R., Kalim, H., Mintaroem, K., Sari, E. K., & Wisnasari, S. (2020). The sinergy of isoquercetin and D-galacturonic acid of Cyclea barbata Miers extract on the migration and apoptosis of neutrophil in rat burn wound. Research J.Pharm.and Tech, 13(7), 3059–3064. https://doi.org/10.5958/0974-360X.2020.00543.0
Kusmardiyani, S., Insanu, M., & Asyhar, M. Al. (2014). Effect a glycosidic flavonol isolated from green grass jelly (Cyclea barbata Miers) leaves. Procedia Chemistry, 13, 194–197. https://doi.org/10.1016/j.proche.2014.12.026
Lin, L. Z., Shieh, H. L., Angerhofer, C. K., Pezzuto, J. M., Cordell, G. A., Xue, L., Johnson, M. E., & Ruangrungsi, N. (1993). Cytotoxic and antimalarial bisbenzylisoquinoline alkaloids from Cyclea barbata. Journal of Natural Products, 56(1), 22–29. https://doi.org/10.1021/np50091a004
Mahadi, R., Rasyid, M., Dharma, K. S., Anggraini, L., Nurdiyanti, R., & Nuringtyas, T. R. (2018). Immunomodulatory and antioxidant activity of green grass jelly leaf extract (Cyclea barbata Miers.) in vitro. Journal of Tropical Biodiversity and Biotechnology, 3(3), 73–79. https://doi.org/10.22146/jtbb.33441
Noviyanti, N., Yueniwati, Y., Ali, M., Rahardjo, B., & Permatasari, G. W. (2020). Cyclea barbata miers ethanol extract and coclaurine induce estrogen receptor α in the development of follicle pre-ovulation. In Open Access Macedonian Journal of Medical Sciences (Vol. 8, Issue A, pp. 434–440). https://doi.org/10.3889/oamjms.2020.4418
Nurlela, J. (2015). The effect of leaf green grass jelly extract (Cyclea L. barbata Miers) to motility in mice BALB/c male that exposed smoke. Majority Medical Journal of Lampung University, 4(4), 57–63.
Oktavia, S. N., Wahyuningsih, E., Andasari, S. D., & Normaidah, N. (2020). Skrining fitokimia dari infusa dan ekstrak etanol 70% daun cincau hijau (Cyclea barbata Miers). Cerata Jurnal Ilmu Farmasi, 11(1), 1–6. https://ejournal.stikesmukla.ac.id/index.php/cerata/article/view/84
Panyaphu, K., Van On, T., Sirisa-Ard, P., Srisa-Nga, P., Chansakaow, S., & Nathakarnkitkul, S. (2011). Medicinal plants of the Mien (Yao) in Northern Thailand and their potential value in the primary healthcare of postpartum women. Journal of Ethnopharmacology, 135(2), 226–237. https://doi.org/10.1016/j.jep.2011.03.050
Pelaczar, M. J., & Chan, E. C. S. (1998). Dasar-dasar Mikrobiologi II. UI Press.
Permanasari, D. A., Sakinah, E. N., & Santosa, A. (2016). The activity of ethanolic extract of Cyclea barbata Miers as inhibitor of bacterial biofilm formation of Salmonella typhi. Journal of Agromedicine and Medical Sciences, 2(2), 24. https://doi.org/10.19184/ams.v2i2.2779
Phumthum, M., Nguanchoo, V., & Balslev, H. (2021). Medicinal Plants Used for Treating Mild Covid-19 Symptoms Among Thai Karen and Hmong. Frontiers in Pharmacology, 12(July), 1–9. https://doi.org/10.3389/fphar.2021.699897
Ramadani, A. P. (2017). Various antimalarial strategies in Indonesia to fight Plasmodium falciparum. Université de Toulouse.
Ramadani, A. P., Paloque, L., Belda, H., Tamhid, H. A., Masriani, Jumina, Augereau, J.-M., Valentin, A., Wijayanti, M. A., Mustofa, & Benoit-Vical, F. (2018). Antiprotozoal properties of Indonesian medicinal plant extracts. Journal of Herbal Medicine, 11, 46–52. https://doi.org/10.1016/j.hermed.2017.06.004
Roosita, K., Kusharto, C. M., Sekiyama, M., Fachrurozi, Y., & Ohtsuka, R. (2008). Medicinal plants used by the villagers of a Sundanese community in West Java, Indonesia. Journal of Ethnopharmacology, 115(1), 72–81. https://doi.org/10.1016/j.jep.2007.09.010
Rusmawati, L., Rahmawan Sjahid, L., & Fatmawati, S. (2016). Pengaruh cara pengeringan simplisia terhadap kadar fenolik dan aktivitas tabir surya ekstrak etanol 70% daun cincau hijau (Cyclea barbata Miers.). Media Farmasi Indonesia, 16(1), 1643–1651. https://doi.org/10.53359/mfi.v16i1.171
Santi, I., Putra, B., & Wahyuni, S. (2017). Uji efek ekstrak etanol daun cincau hijau (Cyclea barbata Miers) sebagai antiinflamasi pada tikus putih yang diinduksi karagen. As-Syifaa, 09(01), 58–66.
Silalahi, M., Khairiah, A., & Nisyawati. (2020). Ethnomedicinal plants and practices related to pregnancy, childbirth, and postpartum healthcare of minangkabau ethnic group, West Sumatra, Indonesia. Biodiversitas, 21(10), 4597–4605. https://doi.org/10.13057/biodiv/d211018
Silalahi, M., Supriatna, J., Walujo, E. B., & Nisyawati. (2015). Local knowledge of medicinal plants in sub-ethnic Batak Simalungun of North Sumatra, Indonesia. Biodiversitas, 16(1), 44–54. https://doi.org/10.13057/biodiv/d160106
Siregar, I. M., & Miladiyah, I. (2011). Protective effects of Cyclea barbata Miers leaves against aspirin-induced gastric ulcer in mice. Universa Medicina, 30(2), 88–94.
Soemarwoto, R., & Iskandar, J. (2021). Plant knowledge richness in the Sundanese upland village: A case study in Sindangsari, West Java, Indonesia. Biodiversitas Journal of Biological Diversity, 22(9), 3722–3735. https://doi.org/10.13057/biodiv/d220916
Srangenge, Y., Oktavia, S., & Irfan, S. G. (2019). Pengaruh pemberian kombinasi ekstrak daun cincau hijau (Cyclea barbata Miers.) dan santan kelapa (Cocos nucifera L.) terhadap profil lipid mencit putih jantan. Jurnal Farmasi Higea, 11(2), 175–183. https://doi.org/http://dx.doi.org/10.52689/higea.v11i2.236
Sujarwo, W., Keim, A. P., Savo, V., Guarrera, P. M., & Caneva, G. (2015). Ethnobotanical study of Loloh: Traditional herbal drinks from Bali (Indonesia). Journal of Ethnopharmacology, 169, 34–48. https://doi.org/10.1016/j.jep.2015.03.079
Sutandio, R. F., Sidharta, B. B., & Ekawati, L. M. (2017). Aktivitas antibakteri ekstrak etanol daun cincau hijau (Cyclea barbata Miers) terhadap Staphylococcus aureus dan Vibrio parahaemolyticus. In Fakultas Teknobiologi Universitas Atma Jaya Yogyakarta.
Thummajitsakul, S., Sitthithaworn, W., & Silprasit, K. (2019). High performance thin layer chromatography fingerprint and antioxidant activities of Cyclea barbata in Thailand. Agricultural and Natural Resources, 53, 479–486.
Tibe, F., Rimpa, M., & Tandi, J. (2018). Uji efektivitas antikolesterol ekstrak etanol daun cincau hijau terhadap tikus putih jantan galur Wistar. Farmakologika Jurnal Farmasi, XV(2), 1–8. https://jfarma.org/index.php/farmakologika/article/view/40/31
Turreira-Garcia, N., Argyriou, D., Chhang, P., Srisanga, P., & Theilade, I. (2017). Ethnobotanical knowledge of the Kuy and Khmer people in Prey Lang, Cambodia. Cambodian Journal of Natural History, 2017(1), 76–101. https://www.researchgate.net/profile/Nerea-Turreira-Garcia-2/publication/318420425_Ethnobotanical_knowledge_of_the_Kuy_and_Khmer_people_in_Prey_Lang_Cambodia/links/596882b70f7e9b80918bce20/Ethnobotanical-knowledge-of-the-Kuy-and-Khmer-people-in-Prey-Lang-Cambodia.pdf
Uddin, M. J., Russo, D., Rahman, M. M., Uddin, S. B., Halim, M. A., Zidorn, C., & Milella, L. (2021). Anticholinesterase Activity of Eight Medicinal Plant Species: In Vitro and in Silico Studies in the Search for Therapeutic Agents against Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine, 2021. https://doi.org/10.1155/2021/9995614
Verpoorte, R., Van Beek, T. A., Siwon, H., & Svendsen, A. B. (1982). Studies on Indonesian medicinal plants. VIII. Screening of some Indonesian Menispermaceae for alkaloids; the isolation of magnoflorine from Pycnarrhena novoguinensis and Cyclea barbata. Pharmaceutisch Weekblad. Scientific Edition, 4(3), 87–88. https://doi.org/10.1007/BF01962251
Wang, X. J., Zhang, Q., Peng, Y. R., Li, L., Qu, J., Liu, Y. B., Xu, S., Ma, S. G., Li, Y., Zou, Z. M., Wang, R. B., & Yu, S. S. (2019). Two azafluoranthene alkaloids and a phytoecdysone from the stems of Cyclea barbata. Journal of Asian Natural Products Research, 21(3), 217–226. https://doi.org/10.1080/10286020.2018.1564137
Yuliarti, O., Chong, S. Y., & Goh, K. K. T. (2017). Physicochemical properties of pectin from green jelly leaf (Cyclea barbata Miers). International Journal of Biological Macromolecules, 103, 1146–1154. https://doi.org/10.1016/j.ijbiomac.2017.05.147
Zheng, X. L., Wei, J. H., Sun, W., Li, R. T., Liu, S. B., & Dai, H. F. (2013). Ethnobotanical study on medicinal plants around Limu Mountains of Hainan Island, China. Journal of Ethnopharmacology, 148(3), 964–974. https://doi.org/10.1016/j.jep.2013.05.051
License
Copyright (c) 2022 The Author(s)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with Sasambo Journal of Pharmacy (SJP), agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Lisensi Creative Commons Atribusi 4.0 Internasional. This license allows authors to use all articles, data sets, graphics and appendices in data mining applications, search engines, web sites, blogs, and other platforms by providing an appropriate reference. The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Sasambo Journal of Pharmacy
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
