Evaluasi penggunaan antibiotik pada neonatus di NICU rumah sakit umum milik pemerintah daerah Banyumas
DOI:
10.29303/sjp.v4i2.231Downloads
Abstract
Infection is one of the leading causes of death in neonatal patients. One of the causes of these infectious diseases is bacteria, so antibiotics are the primary therapy in treating infections. The harmful effects of improper administration of antibiotics are pathogenic bacterial resistance, unwanted drug reactions, and inefficient treatment costs. The purpose of this study was to evaluate the quality of antibiotic use in neonatal patients treated in the Banyumas District Government Hospital NICU from December 2019 to March 2020 by using the Gyssens flow criteria and knowing the outcome of antibiotic use. This research is descriptive and observational. Data obtained from medical records and patient monitoring data with prospective data collection techniques. The inclusion criteria of this study were neonatal patients who were admitted to the NICU and received antibiotics for prophylactic and curative treatment. Total respondent for this study is 56 patients. The Gyssens flow criteria evaluation results were obtained from 53 medical records (94%)tegorized in category 0. There is one medical record each categorized in categories IV D (2%), IV B (2%), and III A (2%). Most of the use of antibiotics is rational. Antibiotics are not a determining factor for the outcome of patients with the same diagnosis and laboratory test results.
Keywords:
Antibiotics, neonates, infection, NICU, GyssensReferences
Amanda Jaya, I. G., Bikin Suryawan, I. W., & Pramitha Rahayu, P. (2019). Hubungan prematuritas dengan kejadian sepsis neonatorum yang dirawat di ruang perinatologi dan neonatal intensive care unit (NICU) RSUD Wangaya kota Denpasar. Intisari Sains Medis, 10(1). https://doi.org/10.15562/ism.v10i1.319
Bibi, S., Chisti, M. J., Akram, F., & Pietroni, M. A. (2013). Ampicillin and Gentamicin Are a Useful First-line Combination for the Management of Sepsis in Under-five Children at an Urban Hospital in Bangladesh. Journal of Health, Population and Nutrition, 30(4). https://doi.org/10.3329/jhpn.v30i4.13418
Departemen Kesehatan RI. (2007). Penatalaksanaan Sepsis Neonatrum. Bakti Husada.
Dinas Kesehatan Kabupaten Banyumas. (2019). Profil Kesehatan Kabupaten Banyumas tahun 2018.
Dini, F. N., Andayani, P., & Rosida, L. (2016). Hubungan Antara Masa Gestasi Dan Kejadian Sepsis Neonatorum Di RSUD Ulin Banjarmasin Periode Juni 2014-Juni 2015. Berkala Kedokteran, 12(2), 175. https://Doi.Org/10.20527/Jbk.V12i2.1865
Hartiningrum, I., & Fitriyah, N. (2019). Bayi Berat Lahir Rendah (Bblr) Di Provinsi Jawa Timur Tahun 2012-2016. Jurnal Biometrika Dan Kependudukan, 7(2), 97. https://Doi.Org/10.20473/Jbk.V7i2.2018.97-104
Hayatullah, M. K., Tjipta, G. D., Sianturi, P., Azlin, E., Lubis, B. M., Syamsidah, & Wahyuni, F. (2017). Terapi Antibiotika Empiris Pada Neonatus. Majalah Kedokteran Nusantara, 107–110.
Kusumo, P. D. (2012). Kolonisasi Mikrobiota Normal Dan Pengaruhnya Pada Perkembangan Sistem Imunitas Neonatal. Majalah Ilmiah Widya, 56–63.
Lutsar, I., Chazallon, C., Trafojer, U., De Cabre, V. M., Auriti, C., Bertaina, C., Calo Carducci, F. I., Canpolat, F. E., Esposito, S., Fournier, I., Hallik, M., Heath, P. T., Ilmoja, M.-L., Iosifidis, E., Kuznetsova, J., Meyer, L., Metsvaht, T., Mitsiakos, G., Pana, Z. D., … Giaquinto, C. (2020). Meropenem Vs Standard Of Care For Treatment Of Neonatal Late Onset Sepsis (Neomero1): A Randomised Controlled Trial. Plos One, 15(3), E0229380. https://Doi.Org/10.1371/Journal.Pone.0229380
Nasir, N., Jamil, B., Siddiqui, S., Iqbal, N. T., Khan, F., & Hussain, R. (2015). Mortality In Sepsis And Its Relationship With Gender. Pakistan Journal Of Medical Sciences, 31(5). https://Doi.Org/10.12669/Pjms.315.6925
Pacifici, G. M. (2011). Pharmacokinetics Of Cephalosporins In The Neonate: A Review. Clinics, 66(7), 1267–1274. https://Doi.Org/10.1590/S1807-59322011000700024
Purwaningsih, A. E. D. A., Rahmawati, F., & Wahyono, D. (2015). Evaluasi Penggunaan Antibiotik Pada Pasien Pediatri Rawat Inap. Jurnal Manajemen Dan Pelayanan Farmasi, 5(3), 211–218.
Puspitasari, D., Hasmono, D., & Rahman, T. (2017). Ampicillin Sulbactam And Cefotaxime Are Similarly Effective In Pediatric Pneumonia. Folia Medica Indonesiana, 52(2), 116. https://Doi.Org/10.20473/Fmi.V52i2.5225
Putra, S. R. (2012). Asuhan Neonatus Bayi Dan Balita Untuk Keperawatan Dan Kebidanan. D-Medika.
Rukmana, R. W. (2018). Evaluasi Rasionalitas Penggunaan Antibiotik Pada Pasien Sepsis Di Intensive Care Unit (Icu) Rsud Dr. Moerwadi Surakarta. Fakultas Farmasi Ums.
Sivanandan, S., Soraisham, A. S., & Swarnam, K. (2011). Choice And Duration Of Antimicrobial Therapy For Neonatal Sepsis And Meningitis. International Journal Of Pediatrics, 2011, 1–9. https://Doi.Org/10.1155/2011/712150
Sutan, R., Mohtar, M., Mahat, A. N., & Tamil, A. M. (2014). Determinant Of Low Birth Weight Infants: A Matched Case Control Study. Open Journal Of Preventive Medicine, 04(03), 91–99. https://Doi.Org/10.4236/Ojpm.2014.43013
Wilar, R., Daud, D., As’ad, S., Febriani, D. B., & Mina, M. (2016). A Comparison Of Neutrophil Gelatinase-Associated Lipocalin And Immature To Total Neutrophil Ratio For Diagnosing Early-Onset Neonatal Sepsis. Paediatrica Indonesiana, 56(2), 107. https://Doi.Org/10.14238/Pi56.2.2016.107-10
Yulita Fitriani, V. (2011). Studi Penggunaan Antibiotika Pada Neonatus Di Nicu Rsal Dr. Ramelan Surabaya. Journal Of Tropical Pharmacy And Chemistry, 1(2), 161–167. https://Doi.Org/10.25026/Jtpc.V1i2.24
Zea-Vera, A., & Ochoa, T. J. (2015). Challenges In The Diagnosis And Management Of Neonatal Sepsis. Journal Of Tropical Pediatrics, 61(1), 1–13. https://Doi.Org/10.1093/Tropej/Fmu079
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