Formulasi gel ekstrak daun sirih cina (Peperomia pellucida L. Kunth) variasi carbopol 940 serta uji fisik dan stabilitasnya

Novita Anggoro; Nur Cholis Endriyatno

doi:10.29303/sjp.v5i1.286

Formulasi gel ekstrak daun sirih cina (Peperomia pellucida L. Kunth) variasi carbopol 940 serta uji fisik dan stabilitasnya

Authors

Novita Anggoro , Nur Cholis Endriyatno

DOI:

10.29303/sjp.v5i1.286

Published:

2024-04-30

Issue:

Vol. 5 No. 1 (2024): April

Keywords:

Chinese betel leaf, Carbopol 940, Gel

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Anggoro, N., & Endriyatno, N. C. (2024). Formulasi gel ekstrak daun sirih cina (Peperomia pellucida L. Kunth) variasi carbopol 940 serta uji fisik dan stabilitasnya . Sasambo Journal of Pharmacy, 5(1), 46–54. https://doi.org/10.29303/sjp.v5i1.286

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Abstract

Chinese betel leaf (Peperomia pellucida L. Kunth) contains tannins, alkaloids, saponins and flavonoids which can inhibit the growth of Propionibacterium acnes bacteria. Gel preparations are suitable for topical therapy of acne. The gelling agent used was carbopol 940. The purpose of this study was to determine the effect and concentration of carbopol 940 which produced the best physical properties of Chinese betel leaf extract gel preparations. This research is an experimental research. Gel preparations were made with various concentrations of carbopol 940 0.5%, 1.0%, 1.5%, and 2.0% then organoleptic examination, homogeneity, pH, adhesion, spreadability, viscosity, skin irritation, physical stability , and hedonic. The data obtained were analyzed with SPSS (trial) using the One Way ANOVA method. The results showed that variations in carbopol 940 concentrations had an effect on organoleptic, adhesiveness, pH, spreadability, viscosity, and hedonics but had no effect on homogeneity, physical stability, and skin irritation. Carbopol 940 concentration of 1.0% produced the best preparation compared to concentrations of 0.5%, 1.5% and 2.0% in terms of physical properties and statistical analysis.

References

Afifi, R., Erlin, E., & Rachmawati, J. (2018). Uji Anti Bakteri Ekstrak Daun Belimbing Wuluh (Averrhoa bilimbi L) Terhadap Zona Hambat Bakteri Jerawat Propionibacterium acnes Secara In Vitro. Quagga: Jurnal Pendidikan Dan Biologi, 10(1), 10–17. https://doi.org/10.25134/quagga.v10i1.803.Abstrak

Angelina, M., Amelia, P., Irsyad, M., Meilawati, L., & Hanafi, M. (2015). Karakterisasi Ekstrak Etanol Herba Katumpangan Air (Peperomia pellucida L. Kunth). Biopropal Industri, 6(2), 53–61.

Asmara, A. P. (2017). Uji Fitokimia Senyawa Metabolit Sekunder Dalam Ekstrak Metanol Bunga Turi Merah (Sesbania grandiflora L . Pers). Al-Kimia, 5(1), 48–59.

Astarina, N. W. G., Astuti, K. W., & Warditiani, N. K. (2013). Skrining Fitokimia Ekstrak Metanol Rimpang Bangle (Zingiber purpureum Roxb.). Jurnal Farmasi Udayana, 2(4), 154.

Bhernama, B. G. (2020). Skrining Fitokimia Ekstrak Etanol Rumput Laut Gracilaria sp. Asal Desa Neusu Kabupaten Aceh Besar. Amina, 2(1), 1–5.

Borman, I. O., Yusriadi, Y., & Sulastri, E. (2015). Gel Anti Jerawat Ekstrak Daun BUta-Buta (Excoecaria agallocha L.) dan Pengujian Antibaktgeri Staphylococcus epidermidis. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 1(2), 65–72. https://doi.org/10.22487/j24428744.2015.v1.i2.6215

Dewi, I. K., Pramono, S., Rohman, A., & Martien, R. (2021). Optimasi Sediaan Gel Fraksi Etil Asetat Tongkol Jagung. Jurnal Jamu Kusuma, 1(2), 57–66. https://doi.org/10.37341/jurnaljamukusuma.v1i2.15

Hayat, J., Akodad, M., Moumen, A., Baghour, M., Skalli, A., Ezrari, S., & Belmalha, S. (2020). Phytochemical Screening, Polyphenols, Flavonoids And Tannin Content, Antioxidant Activities And FTIR Characterization of Marrubium vulgare L. From 2 Different Localities Of Northeast Of Morocco. Heliyon, 6(11), e05609. https://doi.org/10.1016/j.heliyon.2020.e05609

Imansyah, M. Z., & Hamdayani, S. (2022). Uji Aktivitas Ekstrak Etanol Daun Sirih Cina (Peperomia pellucida L) Terhadap Bakteri Propionibacterium acnes. Jurnal Kesehatan Yamasi Makassar, 6(1), 40–47. http://journal.yamasi.ac.id

Indriaty, S., Karlina, N., Hidayati, N. R., Firmansyah, D., Senja, R. Y., & Zahiyah, Y. (2022). Ekstrak Etanol Herba Kemangi Terhadap Bakteri Staphylococcus aureus Formulation And Activity Test Of Deodorant Spray Of Basil Herb Ethanol Extract Against Staphylococcus aureus. Medical Sains : Jurnal Ilmiah Kefarmasian, 7(4), 973–982.

Irianto, Kencana, I. D., Purwanto, & Mardan, M. T. (2020). Aktivitas Antibakteri dan Uji Sifat Fisik Gel Dekokta Sirih Hijau (Piper betle L.) Sebagai Alternatif Pengobatan Mestitis Sapi. Majalah Farmasetik, 16, 204.

Izza, A. R. F., Tambunan, F. M. A., & Maulina, D. (2023). Karakterisasi Dan Skrining Fitokimia Buah Lada Putih (Piperis albi fructus). Indonesian Journal of Health Science, 3(1), 1–6. https://doi.org/10.54957/ijhs.v3i1.356

Kemenkes RI. (2017). Farmakope Herbal Indonesia (II). Kementrian Kesehatan Republik Indonesia. https://doi.org/10.2307/jj.2430657.12

Madelina, W., & Sulistiyaningsih. (2018). Review: Resistensi Antibiotik pada Terapi Pengobatan Jerawat. Jurnal Farmaka, 16(2), 105–117.

Mayefis, D., Marliza, H., & Yufiradani. (2020). Uji Aktivitas Antibakteri Ekstrak Daun Suruhan ( Peperomia pellucida L . Kunth ) Terhadap Propionibacterium acnes. Jurnal Riset Kefarmasian Indonesia, 2(1), 35–41.

Mursal, I. L. P., Kusumawati, A. H., & Puspasari, D. H. (2019). Pengaruh Variasi Konsentrasi Gelling Agent Carbopol 940 Terhadap Sifat Fisik Sediaan Gel Hand Sanitizer Minyak Atsiri Daun Kemangi (Ocimum Sanctum L.). Pharma Xplore : Jurnal Sains Dan Ilmu Farmasi, 4(1), 268–277.

Naibaho, O. H., Yamlean, P. V. Y., & Wiyono, W. (2013). Pengaruh Basis Salep Terhadap Formulasi Sediaan Salep Ekstrak Daun Kemangi (Ocimum sanctum L.) Pada Kulit Punggung Kelinci yang Dibuat Infeksi Staphylococcus aureus. Jurnal Ilmiah Farmasi-UNSRAT, 2(02), 27–34.

Nailufa, Y. (2020). Formulasi Dan Evaluasi Gel Hand Sanitizer Dengan Moisturizer Alga Hijau (Spirulina Platensis) Dan Vitamin E. Syntax Idea, 2(6), 156–165.

Nur Rachmani, E. P., Pramono, S., & Nugroho, A. E. (2018). Aktivitas Antioksidan Fraksi Flavonoid Bebas Andrografolid Dari Herba Sambiloto (Andrographis paniculata). Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ), 1(2), 42–49. https://doi.org/10.35799/pmj.1.2.2018.21642

Paju, N., Yamlean, P. V. Y., & Kojong, N. (2013). Uji Efektivitas Salep Ekstrak Daun Binahong (Anredera cordifolia ( Ten .) Steenis) pada kelinci (Oryctolagus cuniculus) yang Terinfeksi Bakteri Staphylococcus aureus. Jurnal Ilmiah Farmasi - UNSRAT, 2(01), 51–61.

Putrinesia, I., Pratama, Y., Asyikin, N., & Rahmalia, W. (2018). Formulasi dan Uji Aktivitas Krim Pengkelat Merkuri Berbahan Dasar Ekstrak Etanol Alga Coklat (Sargassum sp.). ALCHEMY Jurnal Penelitian Kimia, 14(1), 152. https://doi.org/10.20961/alchemy.14.1.12242.152-163

Roudhatini. (2013). Uji Efektivitas Sediaan Gel Anti Jerawat Minyak Atsiri Daun Jeruk Sambal (X Citrofortunella microcarpa (Bunge) Wijnands) Terhadap Propionibacterium acnes dan Staphylococcus epidermidis. Universitas Tanjungpura.

Rowe, R. C., Sheskey, P. J., & Quinn, M. E. (2009). Handbook of Pharmaceutical Excipients (6th ed.). Pharmaceutical Press and American Pharmacists Association.

Safitri, F. I., Nawangsari, D., & Febrina, D. (2021). Overview: Application of Carbopol 940 in Gel. Advances in Health Sciences Research, 34(Ahms 2020), 80–84. https://doi.org/10.2991/ahsr.k.210127.018

Saraung, V., Yamlean, paulina v, & Citraningtyas, G. (2018). Pengaruh Variasi Basis Karbopol dan HPMC pada Formulasi Gel Ekstrak Etanol Daun Tapak Kuda (Ipomoea pes-caprae (L.) R. Br. dan Uji Aktivitas Antibakteri Terhadap Staphylococcus aureus. Pharmacon, 7(3), 220–229.

Sardana, K., Gupta, T., Kumar, B., Gautam, H. K., & Garg, V. K. (2016). A Cross-Sectional Pilot Study of Antibiotic Resistance In Propionibacterium acnes Strains in Indian Acne Patients Using 16s-RNA Polymerase Chain Reaction: A Comparison Among Treatment Modalities Including Antibiotics, Benzoyl Peroxide, And Isotretinoin. Indian Journal of Dermatology, 61(1), 45–52. https://doi.org/10.4103/0019-5154.174025

Setiani, I., & Endriyatno, N. C. (2023). Formulasi Gel Ekstrak Buah Tomat (Solanum lycopersicum L.) dengan Variasi Konsentrasi HPMC serta Uji Fisiknya. Indonesian Journal of Pharmaceutical Education (e-Journal), 3(3), 378–390. https://doi.org/10.37311/ijpe.v3i3.21186

St. Rahmatullah, Slamet, Ningrum, W. A., & Dewi, N. K. (2020). Formulasi dan Evaluasi Sediaan Gel Hand Sanitizer sebagai Antiseptik Tangan dengan Variasi Basis Karbopol 940 dan TEA. CHMK Pharmaceutical Scientific Journal, 3(3), 189–194.

Su’aida, N., Indah, D. S., & Fitriana, M. (2017). Optimasi Sediaan Gel Fraksi Etil Asetat Buah Katuri (Mangifera casturi kosterm.) dengan Kombinasi Basis CMC-Na dan Basis Carbopol Menggunakan Metoe Simplex Lattice Design. Jurnal of Current Pharmaceutical Sciences, 1(1), 19–24.

Suryani, Putri, A. E. P., & Agustyiani, P. (2017). Formulasi Dan Uji Stabilitas Sediaan Gel Ekstrak Terpurifikasi Daun Paliasa (Kleinhovia Hospita L.) Yang Berefek Antioksidan. Pharmacon, 6(3), 157–169.

Yuska Novi Yanty, Densi Selpia Sopianti, & Cindy Veronica. (2019). Fraksinasi Dan Skrining Fraksi Biji Kebiul (Caesalpinia bonduc (L) ROXB) Dengan Metode KLT (Kromatografi Lapis Tipis). Borneo Journal of Phamascientech, 3(1), 56–64.

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Formulasi gel ekstrak daun sirih cina (Peperomia pellucida L. Kunth) variasi carbopol 940 serta uji fisik dan stabilitasnya

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