Optimasi formula sampo ekstrak etanol daun delima (Punica granatum L.) dengan metode Simplex Lattice Design

Syifaul Jannah; Wahida Hajrin; Nisa Isneni Hanifa

doi:10.29303/sjp.v5i2.347

Optimasi formula sampo ekstrak etanol daun delima (Punica granatum L.) dengan metode Simplex Lattice Design

Authors

Syifaul Jannah , Wahida Hajrin , Nisa Isneni Hanifa

DOI:

10.29303/sjp.v5i2.347

Published:

2024-09-30

Issue:

Vol. 5 No. 2 (2024): September

Keywords:

Pomegranate Leaves, Dandruff, Optimization, Shampoo, Simplex Lattice Design

Articles

Downloads

PDF

How to Cite

Jannah, S., Hajrin, W., & Hanifa, N. I. (2024). Optimasi formula sampo ekstrak etanol daun delima (Punica granatum L.) dengan metode Simplex Lattice Design. Sasambo Journal of Pharmacy, 5(2), 71–82. https://doi.org/10.29303/sjp.v5i2.347

Download Citation

Abstract

Anti-dandruff shampoo on the market still uses zinc pyriton which has the side effect of causing hair loss. Pomegranate leaves have strong antifungal activity against dandruff-causing fungi. This research aims to determine the optimum formula and physical properties of pomegranate leaf shampoo preparations with variations of SLS and cocamide DEA. The ethanol extract of pomegranate leaves was extracted by soxhletation and carried out in a tube test. Eight shampoo formula designs were determined using the SLD method. The shampoo was tested for foam height, pH, and viscosity to obtain the optimum formula. The optimum shampoo preparation was tested for physical properties, including organoleptic tests, homogeneity, foam stability, foam height, pH, and viscosity. The results of the test for the physical properties of the optimum shampoo preparation were verified using the SPSS application with the one-sample t-test method. Pomegranate leaf ethanol extract positively contains alkaloids, flavonoids, tannins, and saponins. The optimization results obtained the optimum shampoo formula, namely a combination of SLS 5.5% and cocamide DEA 15.5%. Optimum formula shampoo has a black color, menthol odor, gel form, ingredients mixed homogeneously, foam stability 81.83%, foam height 9.30 ± 0.26 cm, pH 5.91 ± 0.45, and viscosity 1646.66 ± 220.23 cP.

References

Adjeng, A. N. T., Hairah, S., Herman, S., Ruslin, Muhammad, L. O., Sartinah, A., & Ali, N. F. M. (2019). Skrining Fitokimia dan Evaluasi Sediaan Sabun Cair Ekstrak Etanol 96 % Kulit Buah Salak Pondoh ( Salacca zalacca ( Gaertn .) Voss .) Sebagai Antioksidan. Jurnal Farmasi, Sains, dan Kesehatan, 5(2), 21–24.

Affandy, F., Wirasisya, D. G., & Hanifa, N. I. (2021). Skrining Fitokimia Pada Tanaman Penyembuh Luka di Lombok Timur. Sasambo Journal of Pharmacy, 2(1), 1–6.

Andriani, L. N., Putra, I. G. N., & Tunas, I. K. (2022). Pengaruh Kombinasi Sodium Lauril Sulfat Dan Natrium Klorida Terhadap Karakteristik Sampo Ekstrak Lidah Buaya. Jurnal Riset Kefarmasian Indonesia, 4(3), 366–384. https://doi.org/10.33759/jrki.v4i3.304

Anitha, M., Hemapriya, J., Roselin, M. E., Monisha, D. M., & Swathy, S. R. (2015). Fungal Infections In Dandruff Afflicted Scalps On Medical Students. International Journal of Current Research, 7(12), 1–5.

Bhinge, S. D., Bhutkar, M. A., Randive, D. S., Wadkar, G. H., Todkar, S. S., Kakade, P. M., & Kadam, P. M. (2017). Formulation development and evaluation of antimicrobial polyherbal gel. Annales Pharmaceutiques Francaises, 75(5), 349–358. https://doi.org/10.1016/j.pharma.2017.04.006

Bhinge, Somnath D., Bhutkar, M. A., Randive, D. S., Wadkar, G. H., Todkar, S. S., Savali, A. S., & Chittapurkar, H. R. (2021). Screening of hair growth promoting activity of Punica granatum L. (pomegranate) leaves extracts and its potential to exhibit antidandruff and anti-lice effect. Heliyon, 7(4), 1–10. https://doi.org/10.1016/j.heliyon.2021.e06903

Borda, L. J., & Wikramanayake, T. C. (2015). Seborrheic Dermatitis and Dandruff: A Comprehensive Review. Journal of Clinical & Investigative Dermatology, 3(2), 1–10. https://doi.org/10.13188%2F2373-1044.1000019

Depkes RI. (1985). Cara Pembuatan Simplisia. Jakarta: Departemen Kesehatan RI.

Depkes RI. (1989). Materia Medika Indonesia Jilid V. Jakarta: Departemen Kesehatan RI.

Depkes RI. (2020). Farmakope Indonesia edisi IV. Departemen Kesehatan Republik Indonesia (VI). Jakarta: Kementerian Kesehatan RI.

Emmawati, T., Sidharta, B., Puspita, O. E., & Syafitri, M. H. (2016). Optimasi Formula dan Teknik Pembuatan Sampo Susu Sapi Segar Menggunakan Kombinasi Surfactant d an Co- Surfactant. Majalah Kesehatan, 3(2), 93–111. https://doi.org/10.21776/ub.majalahkesehatan.003.02.6

Fikayuniar, L. (2022). Fitokimia. Pekalongan: NEM. https://books.google.co.id/books?id=-69%5C_EAAAQBAJ

Fiume, M. M., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., … Andersen, F. A. (2013). Safety Assessment of Diethanolamides as Used in Cosmetics. International Journal of Toxicology, 32, 36S-58S. https://doi.org/10.1177/1091581813486300

Harborne, J. B. (1987). Metode Fitokimia : Penuntun Cara Modern Menganalisis Tumbuhan Edisi ke-2. Bandung: ITB.

Harum, N. F., Djayanti, K., Widyanti, S., Ayu Nurjanah, Y., Masruroh, F., Syamsuar, M., … Arrasyid Sukarno, H. (2017). Profil Pengetahuan Mahasiswa Dalam Mencegah Dan Mengatasi Gangguan Ketombe. Jurnal Farmasi Komunitas, 4(1), 113–117.

Hidayah, W. W., Kusrini, D., & Fachriyah, E. (2016). Isolasi, Identifikasi Senyawa Steroid dari Daun Getih-Getihan (Rivina humilis L.) dan Uji Aktivitas sebagai Antibakteri. Jurnal Kimia Sains dan Aplikasi 19, 19(1), 32–37.

Hidayat, F., Hardiyati, I., & Noviati, K. (2021). Formulasi dan uji efektivitas sediaan sampo dari lendir bekicot (Achatina fulica). ISTA Online Technologi Journal, 02(01), 51–56.

Istiharoh, R. (2022). Optimasi Formula Dan Uji Aktivitas Antibakteri Sabun Gel Ekstrak Etanol Daun Kembang Sepatu (Hibiscus Rosa-Sinensis L.). Universitas Mataram. http://eprints.unram.ac.id/id/eprint/30649

Lestari, D. A., Juliantoni, Y., & Hasina, R. (2020). Optimasi formula sampo ekstrak daun pacar air (Impatiens balsamina L.) dengan kombinasi natrium lauril sulfat dan cocamide DEA. Sasambo Journal of Pharmacy, 2(1), 23–31. https://doi.org/10.29303/sjp.v2i1.72

Malonda, T. C., Yamlean, P. V. Y., & Citraningtyas, G. (2017). Formulasi Sediaan Sampo Antiketombe Ekstrak Daun Pacar Air ( Impatiens Balsamina L .) Dan Uji Aktivitasnya Terhadap Jamur Candida Albicans Atcc 10231 Secara In Vitro. Pharmacon Jurnal Ilmiah Farmasi, 6(4), 97–109.

Mitsui, T. (1997). New Cosmetic Science (First Edit). Belanda: Elsevier Science.

Muhammad, A., Tarigan, D. M., & Alridiwirsah. (2017). Budidaya Tanaman Obat & Rempah. Medan: UMSU Press.

Murti, I. K. A. Y., Putra, I. P. S. A., Suputri, N. N. K. T., Wijayanti, N. P. D., & Yustiantara, P. S. (2018). Optimasi Konsentrasi Olive Oil Tehadap Stabilitas Fisik Sediaan Sabun Cair. Jurnal Farmasi Udayana, 6(2), 15. https://doi.org/10.24843/jfu.2017.v06.i02.p03

Nasmety, A., Pramesti, K., & Septiani, I. (2019). Pengaruh Konsentrasi Cocamide Dea Sebagai Surfaktan Pada Pembuatan Sampo Ekstrak Daun Alamanda Effect of Cocamide Dea Concentration as Surfactant on Making Alamanda Leaf Extract Shampoo. IJMS-Indonesian Journal On Medical Science, 6(2), 78–82.

Nathan, A. (2008). Scalp conditions. In Managing Symptoms in the Pharmacy (hal. 183–192). London: Pharmaceutical Press.

Nurhikma, E., Antari, D., & Tee, S. A. (2018). Formulasi Sampo Antiketombe Dari Ekstrak Kubis (Brassica oleracea Var. Capitata L.) Kombinasi Ekstrak Daun Pandan Wangi (Pandanus amaryllifolius Roxb). Jurnal Mandala Pharmacon Indonesia, 4(1), 61–67. https://doi.org/https://doi.org/10.35311/jmpi.v4i1.25

Pangesti, C., Nopiyanti, V., & Widyasti, J. H. (2021). Uji Aktivitas Antihiperglikemia Ekstrak Etanol Daun Delima Putih (Punica granatum L.) pada Mencit Jantan (Mus musculus L.) yang Diinduksi Aloksan. Jurnal Farmasi (Journal of Pharmacy), 10(2), 1–7. https://doi.org/10.37013/jf.v10i2.136

Pargiyanti. (2019). Optimasi Waktu Ekstraksi Lemak Dengan Metode Soxhlet Menggunakan Perangkat Alat Mikro Soxhlet. Indonesian Journal of Laboratory, 1(2), 1624.

Pratama, R. N., Widarta, I. W. R., & Darmayanti, L. P. T. (2017). Pengaruh Jenis Pelarut dan Waktu Ekstraksi Dengan Metode Soxhletasi Terhadap Aktivitas Antioksidan Minyak Biji Alpukat (Persea americana Mill.). Media Ilmiah Teknologi Pangan (Scientific Journal of FoodTechnology), 4(2), 85–93.

Prayadnya, I., Sadina, M., Kurniasari, N., Wijayanti, N., & Yustiantara, P. (2017). Optimasi Konsentrasi Cocamid Dea Dalam Pembuatan Sabun Cair Terhadap Busa Yang Dihasilkan Dan Uji Hedonik. Jurnal Farmasi Udayana, 6(1), 11–14.

Prayoga, D. G. E., Nocianitri, K. A., & Puspawati, N. N. (2019). Identifikasi Senyawa Fitokimia Dan Aktivitas Antioksidan Ekstrak Kasar Daun Pepe (Gymnema Reticulatum Br.) Pada Berbagai Jenis Pelarut. Jurnal Ilmu dan Teknologi Pangan, 8(2), 111–121.

Putrima, B. N., Arumsari, A., & Kurniaty, N. (2019). Uji Aktivitas Antibakteri Ekstrak dan Fraksi Daun Delima ( Punica Granatum L .) Terhadap Bakteri Penyebab Jerawat (Propionibacterium Acnes), at Prosiding Farmasi, Agustus 2019 (pp. 602–607).

Rahmadani. (2012). Pengaruh Pemanfaatan Jeruk Nipis Terhadap Penyembuhan Ketombe Kering Di Kulit Kepala. Universitas Negeri Padang.

Ramadhani, R. A., Riyadi, D. H. S., Triwibowo, B., & Kusumaningtyas, R. D. (2017). Review Pemanfaatan Design Expert untuk Optimasi Komposisi Campuran Minyak Nabati sebagai Bahan Baku Sintesis Biodiesel. Jurnal Teknik Kimia dan Lingkungan, 1(1), 11–16. https://doi.org/10.33795/jtkl.v1i1.5

Regina, O., Sudrajad, H., & Syaflita, D. (2018). Pengukuran Viskositas Menggunakan Viskometer Alternatif. Jurnal Geliga Sains, 6(2), 127–132.

Rowe, R. C., Sheskey, P. J., & Quinn, M. E. (2009). Handbook of Pharmaceutical Excipients. Pharmaceutical Press (Sixth). UK: Pharmaceutical Press. https://doi.org/10.1016/B978-0-12-820007-0.00032-5

Sari, I., & Nursanty, R. (2017). Skrining fitokimia dan uji aktivitas antibakteri ekstrak N-heksan dan metanol dari daun tutup bumi (Elephantopus scaber) terhadap pertumbuhan bakteri Methicillin resistant staphylococcus aureus (MRSA) irma, at Prosiding Seminar Nasional Biotik (pp. 397–402).

Schwartz, J. R., & Dawson, T. L. (2017). Dandruff and Seborrheic Dermatitis. In R. Baran & H. Maibach (Ed.), Textbook of Cosmetic Dermatology (Fifth, hal. 248–258). London: CRC Press. https://doi.org/10.1001/jama.1926.02670370006003

Sorescu, A.-A., Nuta, A., Ion, R.-M., & Iancu, L. (2018). Qualitative Analysis of Phytochemicals from Sea Buckthorn and Gooseberry. In T. Asao & M. Asaduzzaman (Ed.), Phytochemicals - Source of Antioxidants and Role in Disease Prevention (hal. 161–177). London: IntechOpen. https://doi.org/10.5772/intechopen.77365

Sudarman, R., Nurbaits, A., & Pasonang Sihombing, R. (2021). Pengaruh Konsentrasi Garam Terhadap Viskositas Sabun Cair Berbasis Surfaktan Anionik. Jurnal Pendidikan Kimia dan Ilmu Kimia, 4(1), 39–44.

Sudhir, M. S., Venkata Nadh, R., & Radhika, S. (2013). Antifungal Activities Of Novel 1,2,3-Benzotriazole Derivatives Synthesized By Ultrasonic And Solvent-Free Conditions. Drug Invention Today, 5(2), 126–132. https://doi.org/10.1016/j.dit.2013.06.004

Tee, S. A., & Badia, E. (2019). Uji Efektivitas Shampo Antikutu Rambut Ekstrak Daun Sirsak ( Annonna muricata L .) Secara In Vitro. Jurnal Warta Farmasi, 8(2), 1–9.

Wahyuni, W. T. (2022). Kajian Budi Daya, Statistik Produksi, dan Pemanfaatan Temu Hitam. Bogor: IPB Press. https://books.google.co.id/books?id=%5C_-txEAAAQBAJ

Wendersteyt, N. V., Wewengkang, D. S., & Abdullah, S. S. (2021). Uji Aktivitas Antimikroba Dari Ekstrak Dan Fraksi Ascidian Herdmania Momus Dari Perairan Pulau Bangka Likupang Terhadap Pertumbuhan Mikroba Staphylococcus Aureus, Salmonella Typhimurium dan Candida Albicans. Pharmacon, 10(1), 706–712.

Widowati, P., Zalfani, Q., Lestari, A., Syahbana, S., Putri, N., Sena, R., … Sukorini, A. (2020). Identifikasi pengetahuan dan penggunaan produk antiketombe pada mahasiswa UPN Veteran Surabaya. Jurnal Farmasi Komunitas, 7(1), 31–37. https://doi.org/https://doi.org/10.20473/jfk.v7i1.21661

Wilkinson, J. B., & Moore, R. J. (1982). Harry`s Cosmeticology. London: George Godwin.

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with Sasambo Journal of Pharmacy (SJP), agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Lisensi Creative Commons Atribusi 4.0 Internasional. This license allows authors to use all articles, data sets, graphics and appendices in data mining applications, search engines, web sites, blogs, and other platforms by providing an appropriate reference. The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Sasambo Journal of Pharmacy
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

Optimasi formula sampo ekstrak etanol daun delima (Punica granatum L.) dengan metode Simplex Lattice Design

Authors

DOI:

Published:

Issue:

Keywords:

Articles

Downloads

How to Cite

Abstract

References

License

Current Issue

Information

Developed By

Official Website Of

Jurnal Farmasi, Fakultas Kedokteran, Universitas Mataram

Contact Us

Official link

Share & Follow