Vol. 6 No. 1 (2025): April
Open Access
Peer Reviewed

Physical characterization of paracetamol granule preparation using goroho banana starch as binder and disintegrant

Authors

Mutmainnah Mutmainnah , Abulkhair Abdullah , Sandra Lewa , S. Masitah Muhlis

DOI:

10.29303/sjp.v6i1.393

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Received: Jul 22, 2024
Accepted: Feb 03, 2025
Published: Apr 30, 2025

Abstract

The research aims to formulate Goroho banana starch (GBS) as a binding and disintegrating agent in paracetamol (PCT) granule preparations. PCT granules were made using GBS as a binding agent in 3 concentrations of 6, 8, and 10%, respectively. PCT granules using GBS as a disintegrating agent were made with three concentrations of 10, 15, and 20%, respectively. Paracetamol granules are made using the wet granulation method. Granules were evaluated using six parameters: flow rate, angle of repose, water content, bulk density, tapped density, and compressibility index. GBS as a binder showed good physical properties. F1 (6% GBS) showed a flow rate of 8.1 g/sec, an angle of repose of 22.9 degrees, a water content of 1.2%, and a compressibility index of 19.3%. F2 (8% GBS) shows a flow rate of 8.5 g/sec, an angle of repose of 18.5 degrees, a water content of 1.3%, and a compressibility index of 17.6%. F3 (10% GBS) shows a flow rate of 9.0 g/sec, an angle of repose of 21.5 degrees, a water content of 1.4%, and a compressibility index of 19.3%. 8% GBS showed the best physical properties as a binding agent for PCT granules. GBS as a disintegrating agent, shows excellent physical properties. F4 (10% GBS) shows a flow rate of 12.9 g/sec, an angle of repose of 17.0 degrees, a water content of 4.3%, and a compressibility index of 13.3%. F5 (15% GBS) shows a flow rate of 11.4 g/sec, an angle of repose of 18.0 degrees, a water content of 1.4%, and a compressibility index of 14.5%. F6 (20% GBS) shows a flow rate of 10.7 g/sec, an angle of repose of 23.0 degrees, a water content of 3.5%, and a compressibility index of 14.6%. 10% GBS showed the best physical properties as a disintegrants agent for PCT granules.

Keywords:

binder, disintegrant, goroho banana, paracetamol granules, starch

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Author Biographies

Mutmainnah Mutmainnah, Universitas Khairun

Abulkhair Abdullah, Universitas Khairun

Sandra Lewa, Universitas Muhammadiyah Manado

S. Masitah Muhlis, Universitas Muhammadiyah Manado

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How to Cite

Mutmainnah, M., Abdullah, A., Lewa, S., & Muhlis, S. M. (2025). Physical characterization of paracetamol granule preparation using goroho banana starch as binder and disintegrant. Sasambo Journal of Pharmacy, 6(1), 7–13. https://doi.org/10.29303/sjp.v6i1.393