Vol. 6 No. 1 (2025): April
Open Access
Peer Reviewed

Formulasi serum antiaging nanopartikel emas dengan fraksi daun sirih hutan gambut Kalimantan (Piper aduncum)

Authors

Jenny Blessia Gerung , Tiya Sulistia , Elia Yulita , Ni Wayan Septia Sametri , Sudarman Rahman

DOI:

10.29303/sjp.v6i1.401

Downloads

Received: Jul 30, 2024
Accepted: Mar 04, 2025
Published: Apr 30, 2025

Abstract

Free radicals are molecules with unpaired electrons that are reactive and unstable. Gold nanoparticles (AuNPs) have an antioxidant reducing Au3+ to Au+ which can stabilize free radicals. This research aims to characterize AuNPs, formulate and evaluate AuNPs antiaging serum with sirih hutan leaves fraction and antioxidant activity test. The research method used was maceration, sirih hutan leaves were extracted using 96% ethanol, fractionation using n-hexane, biosynthesis of AuNPs, formulation, and antioxidant activity using the DPPH method. The data analysis used One Way Anova test and post hoc Tukey (CI 95%). The research results showed that ethanol extract and n-hexane fraction were obtained at 132.5059 g and 18.3804 g respectively. Biosynthesis characterization of AuNPs have a particle size of 424.9 nm. Formulation and evaluation of AuNPs formulation were generally obtained according to SNI. The antioxidant activity of the formulation and vitamin C showed that the percentage of DPPH increased with increasing concentration, IC50 values of the formulaion and vitamin C showed 35.21 ± 0.95; 17.95 ± 0.34 ppm respectively. Based on One Way Anova test, there was significant difference in each concentration in the percentage of DPPH (p<0.05). and the formulation and vitamin C were classified as very strong antioxidants (IC50<50).

Keywords:

sirih hutan leaves, gold nanoparticles, formulation, antioxidants

References

Aktumsek, A., Zengin, G., Guler, G.O., Cakmak, Y.S., & Duran, A. (2016). Antioxidant potentials and anticholinesterase activities of methanolic and aqueous extracts of three endemic Centaurea L. species. Food Chem. Toxicol. 55:290–296. https://doi.org/10.1016/j.fct.2013.01.018.

Ali, S. S., Ahsan, H., Zia, M. K., Siddiqui, T., & Khan, F. H. (2020). Understanding oxidants and antioxidants: Classical team with new players. Journal of Food Biochemistry, 44(3). https://doi.org/10.1111/jfbc.13145.

Arina, N. B., & Rohman, A. (2015). The phenolic contents and antiradical activity of Indonesian Phyllantus urinaria L. International Food Research Journal. 20(3):1119-1124.

Boly, R., Lamkami, T., & Guissou, I. (2016). DPPH free radical scavenging activity of two extracts from agelanthus dodoneifolius (Loranthaceae) leaves. Int J Toxicol Pharmacol Research, 8(1),29-34. https://www.semanticscholar.org/paper/DPPH-free-radical-scavenging-activity-of-two-from-Boly-Lamkami/77f38b4576ec817d93e49a581d84b51d80b05a58h.

Lai-Cheong, J. E., & McGrath, J. A. (2017). Structure and function of skin, hair and nails. Medicine (United Kingdom). 45(6):347–351. http//doi.org/10.1016/j.mpmed.2017.03.004.

Najib, Ahmad. (2018). Ekstraksi Senyawa Bahan Alam. Deepublish.

Neha, K., Haider, M. R., Pathak, A., & Yar, M. S. (2019). Medicinal prospects of antioxidants: A review. European Journal of Medicinal Chemistry, 178, 687–704.https://doi.org/10.1016/j.ejmech.2019.06.010h.

Putri, F.A., Diharmi, A., & Karnila., R. (2023). Identifikasi Senyawa Metabolit Sekunder pada Rumput Laut Cokelat (Sargassum plagyophyllum) dengan Metode Fraksinasi. Jurnal Teknologi dan Industri Pertanian Indonesia. 15(1):41-46. https://doi.org/10.17969/jtipi.v15i1.23318.

Rudiana, T., Indiatmoko, D, D., & Rohim, D. (2021). Aktivitas Antioksidan dan Profil Senyawa Metabolit Sekunder Ekstrak Kulit Batang Alkesa (Pouteria campechiana). (2021). Chimica et Natura Acta, 9(1). https://doi.org/10.24198/cna.v9.n1.33567.

Sartika D., Rahmi, M., & Noor fajriwianti, D. (2021). Uji Efektivitas Salep Ekstrak Daun Sirih Hutan (Piper aduncum L.) Terhadap Penyembuhan Luka Bakar Pada Mencit Putin Jantan. Jurnal Katalisator. 6(2):308–316)http://doi.org/10.22216/jk.v5i2.5717.

Slamet, S., & Anggun, B.D. (2020). Uji Stabilitas Fisik Formula Sediaan Gel Ekstrak Daun Kelor (M. oleifera). Jurnal Ilmu Kesehatan. 13(2):115-122. http://doi.org/10.48144/jiks.v13i2.260.

Sovawi, A. C., Harjono, H., & Kusuma, S.B.W. (2016). Sintesis Nanopartikel Emas dengan Bioreduktor Ekstrak Buah Jambu Biji Merah (Psidium guajava L.). Indonesian Journal of Chemical Science. 5(3):169-173. http://doi.org/10.15294/ijcs.v5i2.11704.

Susanty, S., & Bachmid, F. (2016). Perbandingan Metode Ekstraksi Maserasi dan Refluks Terhadap Kadar Fenolik dari Ekstrak Tongkol Jagung (Zea mays L.). Jurnal Konversi, 5(2), 87. https://doi.org/10.24853/konversi.5.2.87-92).

Vellayanti, S. (2020). Formulasi dan karakterisasi sediaan serum nanopartikel emas daun tin (Ficus carica L.). Skripsi. Universitas Islam Indonesia.

Wardiyah, (2016). Kimia Organik. Jakarta. Penerbit Kementerian Kesehatan Republik Indonesia.

Wiyanto, A. & Nurhamidah. (2023). Analisis Pengaruh Nano Partikel terhadap Aktivitas Anti Aging. Jurnal Lentera:Penelitian dan Pengabdian Masyarakat. 4(1):25-29.

Yanti, D. & Nurhayati, N. (2022). Formulasi sediaan serum mengandung nanopartikel Emas yang dibuat dengan bioreduktor ekstrak Daun mangkokan (polyscias scutellaria). Jurnal Katalisator. 2(1):45-53.

Author Biography

Jenny Blessia Gerung, Program Studi Farmasi FMIPA Universitas Palangka Raya

Downloads

Download data is not yet available.

How to Cite

Gerung, J. B., Sulistia, T., Yulita, E., Sametri, N. W. S., & Rahman, S. (2025). Formulasi serum antiaging nanopartikel emas dengan fraksi daun sirih hutan gambut Kalimantan (Piper aduncum). Sasambo Journal of Pharmacy, 6(1), 20–25. https://doi.org/10.29303/sjp.v6i1.401