Formulasi dan evaluasi karakter fisik sediaan gel ekstrak etanol daun salam (Syzygium polyanthum)
DOI:
10.29303/sjp.v2i1.57Downloads
Abstract
Abstrak: Bay leaves (Syzygium polyanthum) are known to have antioxidant effects that can neutralize free radicals found in the skin. The objectives of this research are to formulate the ethanol extract of bay leaves into gel formulation and evaluate the physical properties of gel formulation. Ethanol extract of bay leaves was obtained through the maceration method with 70 % ethanol as a solvent. The thick ethanol extract of bay leaves was formulated into gel formulation with CMC – Na as a gelling agent, glycerin as a humectant, methyl paraben as a preservative, and aquadest as a solvent. After the freeze-thaw test was done, there was no change found in organoleptic but there were changes in pH, spreadability, and adhesion. The pH of gel preparation before being in storage was 5 and after being in storage was 6. In the spreadability, gel formulation spread 5,5 cm before being in the storage, and 5,1 cm after being in the storage. Gel adhesion has a sticky time of 8.35 seconds before in being storage and 8.45 seconds after being in storage.
References
Ansel, H. C. (2005) Pengantar Bentuk Sediaan Farmasi. Diterjemahkan oleh Ibrahim, F. Jakarta: UI Press.
Aponno, J. V, Yamlean, P.V.Y. & Supriati, H.S. (2014). Uji Efektivitas Sediaan Gel Ekstrak Etanol daun Jambu Biji (Psidium guajava Linn) Terhadap Penyembuhan Luka yang Terinfeksi Bakteri Staphylococcus aureus pada Kelinci (Orytolagus cuniculus). Jurnal Ilmiah Farmasi. Vol. 3, No. 3, Hal. 279–286.
Asngad, A., Aprilia B. R., dan Npitasari. (2018). Kualitas Gel Pembersih Tangan (Hand sanitizer) dari Ekstral Batang Pisang dengan Penambahan Alkohol, Trklosan dan Gliserin yang Berbeda Dosisnya. Bioeksperimen. Vol. 4, No. 2, Hal. 61-70.
Bahriul, P., Nurdin, R., dan Anang W. (2014). Uji Aktivitas Antioksidan Ekstrak Daun Salam (Syzygium polyanthum) dengan Menggunakan 1,1-Difenil-2-Pikrilhidrazil. Jurnal Akademia Kimia. Vol. 3, No. 3, Hal. 143-149.
Birowo, A., Suhartono, E., Setiawan, B. (2004). Aktivitas Antioksidan dan Enzimatik Infus Daun Belimbing Wuluh (Averrhoa bilimbi Linn) dan Potensinya Sebagai Analgetik. Skripsi. Banjar baru: Universitas Lambung.
Dewi, S. (2016). Formulasi dan Uji Stabilitas Fisik Gel Ekstrak Etanol Daun Kemangi (Ocimum sanctum L.) Sebagai Sediaan Hand Sanitizer. Skripsi. Makassar: UIN.
Diana, D. Z., and Thaman, A. L. (2006). Cosmetic Formulation of Skin Care Product. New York: Taylor and Francis Group.
Garg, A., Aggarwal, D., Garg, S., dan Sigla, A.K. (2002). Spreading of Semisolid Formulation An Update. India: Pharmaceutical Tecnology.
Gillespie, R.J. dan Paul. (2001). Chemical Bonding and Molecular Geometry. London: Oxford University Press.
Gowri, S.S., dan Vasantha, K. (2010). Phytochemical Screening and Antibacterial Activity of Syzygium cumini (l.) (myrtaceae) Leaves Extracts. Jurnal Internasional. Vol. 2, No. 2, Hal. 1569-73.
Hasanah, N. (2015). Aktivitas Antioksidan Ekstrak Etanol Daun Salam, Univ. Perkalongan. Jurnal Pena Medika. Vol. 5, No. 1, Hal. 55-59.S
Herdiana, Y. (2007). Formulasi Gel Uudesilenil Fenilalanin Dalam Aktivitas Sebagai Pencerah Kulit. Jurnal Ilmiah Kefarmasian. Vol. 3, No. 1, Hal. 27.
Hidayati, M.D., Ersam, T., Shimizu, K., dan Fatmawati, S. (2017). Antioxidant Activity of Syzygium polyanthum Wight Extracts. Indonesian Journal of Chemistry. Vol. 17, No. 1, Hal. 49-53.
Ida N. dan Noer S. F. (2012). Uji Stabilitas Fisik Gek Ekstrak Lidah Buaya (Aloe vera L.). Majalah Farmasi dan Farmakologi. Vol. 16, No. 2, Hal. 79-84.
Khristantyo, Y., Astuti, I.Y., dan Suparman. (2011). Profil Sifat Fisik Gel Antioksidan Ekstrak Buncis (Phaseolus vulgaris L) dengan Basis CMC-Na. Jurnal Farmasi Indonesia. Vol. 8, No. 1, Hal. 125-39.
Kikuzaki, H., Hisamoto, M., Hirose, K., Akiyama, K., and Taniguchi, H. (2002). Antioxidants Properties of Ferulic Acid and Its Related Compound. Journal Agric Food Chem. Vol. 50, Hal. 2161-2168.
Kuncari, E. S., Iskandarsyah dan Pratiwi. (2014). Evaluasi, Uji Stabilitas Fisik dan Sinersis Sediaan Gel Yang Mengandung Minoksidil, Apigenin dan Perasan Herba Seledri (Apium graveolens L.). LIPI. Vol. 42, No. 4, Hal. 213.
Laksmi, B. S., Yasni, S., dan Sudirman, I. (2007) Mekanisme Antibakteri Lb. Plantarumkik dan Monoasilgliserol Minyak Kelapa Terhadap Bakteri Patogen Pangan. Jurnal Teknologi dan Industri Pangan. Vol. 8, No. 2, Hal. 126.
Lathifah, Q. A. Y., 2008. Uji Efektifitas Ekstrak Kasar Senyawa Antibakteri pada Buah Belimbing Wuluh (averrhoa bilimbi l.) dengan Variasi Pelarut. Skripsi. Universitas Islam Negeri Malang.
Lena, M., dan Nining, S. (2015). Formulasi Gel Ekstrak Etanol Kulit Buah Manggis (Garcinia mangostana L.) dengan Variasi Gelling Agent Sebagai Sediaan Luka Bakar. Pharmaciana. Vol. 5, No. 1, Hal. 43-52.
Mindawarnis dan Desti, H. (2017). Formulasi Sediaan Tablet Ekstrak Daun Nangka (artocarpus heterophytus L.) dengan Variasi Polivis Pirolidon (PVP) sebagai Pengikat dan Evaluasi Sifat Fisikya. Jurnal Kesehatan. Vol. 12, No. 1, Hal. 12-26.
Miranti, L. (2009). Pengaruh Konsentrasi Minyak Atsiri Kencur (Kaemferia galangal) Dengan Basis Salep Larut Air Terhadap Sifat Fisik Salep dan Daya Hambat Bakteri Staphylococcus aureus Secara in vitro. Skripsi. Surakarta: Fakultas Farmasi Univeritas Muhammadiyah Surakarta.
Murhadi, AS, S., & Susilawati (2007). Aktivitas Antibakteri Daun Salam (Syzygium polyanta) dan Daun Pandan (Pandanus amarylifolius). Jurnal Teknologi dan Pangan. Vol. 12, No. 1, Hal. 17-24.
Nutrisia, A., S. (2015). Formulasi dan Uji Stabilitas Fisik Sediaan Gel Ekstrak Daun Ketepeng Cina (Cassia alataL.). Jurnal Kefarmasian Indonesia. Vol. 5, No. 1, Hal. 80.
Pujiastuti, A., & Kristiani, M. (2019). Formulasi dan Uji Stabilitas Mekanik Hand and Body Lotion Sari Buah Tomat (Licopersicon esculentum Mill) sebagai Antioksidan. Jurnal Farmasi Indonesia. Vol 16. No. 1, Hal. 42–55.
Rahman, N., Bahrul, P., dan Diah, A.W.M. (2014). Uji Aktivitas Antioksidan Ekstrak Daun Salam (Syzygium polyanthum) dengan Menggunanakan 1,1-difenil-2-pikrilhidrazil. Jurnal Akademika Kimia. Vol. 3, No. 3, Hal. 368-74.
Rowe, R.C., Paul, J.S., Queen, dan Marian, E.Q. (2009). Handbook of Pharmaceutical Exipients. 6th edition. London: Pharmaceutical Press.
Sarma, A.D., Mallick, A.R., and Ghosh, A.K. (2010). Free Radicals and Their Role in Different Clinical Conditions. Jurnal Internasional. Vol. 1, No. 3, Hal. 185. .
Sudjono, T. A., Honniasih, M., dan Pratimasari, Y. R. (2012). Pengaruh Konsentrasi Gelling Agent Karbomer 934 dan HPMC pada Formulasi Gel Lendir Bekicot (Achatina fulica) Terhadap Kecepatan Penyembuhan Luka Bakar pada Punggung Kelinci. Pharmacon Pharmaceutical Journal of Indonesia. Vol. 13, No. 1, Hal. 6-11.
Sutriningsih, Sagala, Z., dan Marhamah. (2018). Formulation And Irritation Test Of Antibacterial Gel From Star Fruit Leaves (Averrhoa Bilimbi Linn.) Ethanol Extracted Againts Bacteria Staphylococcus Aureus and Pseudomonas Aeruginosa. Jurnal Sains and Teknologi. Vol. 2, No. 1, Hal. 448-458.
Tan, J.K.L. (2009). Topical Acne Therapy: Current and Advanced Option for Optimizing Adherence. Skin Theraphy Letter. Vol. 4, No. 2, Hal. 130.
Tranggono, L. (2007). Buku Pegangan Ilmu Pengetahuan Osmetik. Jakarta: PT. Gramedia Pustaka Utama.
Trilestari. (2002). Hand and Body lotion : Pengaruh Penambahan Nipagin, Nipasil dan Campuran Keduanya Terhadap Stabilitas Fisika dan Efektifitasnya sebagai Anti Jamur. Skripsi. Yogyakarta : Fakultas Farmasi Universitas Gadjah Mada.
Wardani, L.P. (2019). Efek Penyembuhan Luka Bakar Gel Ekstrak Etanol Daun Siri (Piper betle) pada Kulit Punggung Kelinci. Skripsi. Surakarta: UMY.
Yanhendri dan Yenny Satya (2012). Berbagai Bentuk Sediaan Topikal dalam Dermatologi. Jurnal CDK. Vol. 39, No. 6, Hal. 423.
Young J. (2004). Triethanolamine. Journal of Chemical Education. Vol. 81, No. 1, Hal. 24.
Yunus N. (2015). Identifikasi Senyawa Flavonoid Ekstrak Etanol Daun Salam (Syzygium polyanthum) Asal Gorontalo Dengan Menggunakan Metode Kromatografi Lapis Tipis. Skripsi. Gorontalo: UNG.
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