Sasambo Journal of Pharmacy 2022-09-30T10:18:36+00:00 apt. Nisa Isneni Hanifa, M.Sc. Open Journal Systems <p align="justify"><strong><a href="">Sasambo Journal of Pharmacy </a> (p-ISSN: <a href=";1592614815&amp;1&amp;&amp;2020">2723-2824</a>; e-ISSN: <a href=";1592615312&amp;1&amp;&amp;2020">2723-2832</a>) </strong> is a scientific journal publishing original articles research in pharmaceutical science. The Journal is managed by<strong> <a href="">the Pharmacy Study Program</a>, <a href="">Mataram University</a></strong></p> Perspektif mahasiswa farmasi universitas mataram terhadap vaksinasi COVID-19 2022-08-28T03:01:04+00:00 Nur Amalina Sabdarrifa Baiq Bismiranti Haris Zulfiana Fitrianingrum Annas Candra Eka Puspitasari <p>COVID-19 is an infectious disease caused by SARS-CoV-2 with a high transmission rate. The Indonesian Ministry of Health made efforts to contain the spread of the virus by conducting a vaccination program. This study’s objective to examine the extent to which UNRAM Pharmacy students provide the opportunity to vaccinate, the known types of COVID-19 vaccines, and student responses to the outbreak of the emergence of a new variant, namely the COVID-19 Delta variant. The method used in this study was <em>cross-sectional,</em> with a sample of 163 active students of Pharmacy UNRAM. Sampling was done boldly by using google forms<strong>. </strong>The results of the study were 98% of respondents started to vaccinating against COVID-19. There are three types of vaccines known to students, namely Sinovac, Astra Zeneca, and Moderna.</p> 2022-09-30T00:00:00+00:00 Copyright (c) 2022 Nur Amalina Sabdarrifa, Baiq Bismiranti Haris, Zulfiana Fitrianingrum Annas, Candra Eka Puspitasari Cyclea barbata L. Miers.: Penggunaan tradisional, fitokimia, dan aktivitas farmakologi 2022-08-19T07:21:59+00:00 Surya Febrianto Fradnya Vrianka Praharsini Zulfiana Fitrianingrum Annas Nisa Isneni Hanifa <p>Indonesian people still favor the use of traditional medicine because they believe its side effects are lower than synthetic drugs. One of the plants that can be used in traditional medicine is <em>Cyclea barbata</em> L. Miers, or green grass jelly. This study aimed to explain and summarize the traditional use, phytochemical content, and pharmacological activity of <em>C. barbata</em>. All information on <em>C. barbata</em> was collected from various electronic databases (Google Scholar, Science Direct, and PubMed) using important and related keywords. Secondary metabolites found in stems, roots, and leaves are alkaloids and flavonoids. The pharmacological activities of <em>C. barbata</em> include antibacterial, antioxidant, anti-plasmodial, immunomodulator, Alzheimer, anti-inflammatory, anti-cholesterol, and antiulcer. Although <em>C. barbata</em> has been used empirically, further research is still needed to ensure the effectiveness and safety of this plant.</p> 2022-09-30T00:00:00+00:00 Copyright (c) 2022 The Author(s) Penetapan rendemen dan kandungan kimia ekstrak daun katuk (Sauropus androgynus (L.) Merr.) berdasarkan perbedaan metode pengeringan 2022-08-26T01:46:27+00:00 Fara Azzahra <p>Katuk leaves contain chemicals in the form of alkaloids, triterpenoids, saponins, tannins, polyphenols, glycosides and flavonoids, so they are widely used as antioxidants. One factor can affect in chemical content and yield extract is the drying method. The purpose of this study was to determine the effect of different drying methods on yield and chemical content of katuk leaf extract. This research method was experimental Posttest Only Design. Katuk leaves were dried using wind, oven, sun and continued by maceration with ethanol 96% as solvent. The macerate was filtered and air-dried to thick extract which was calculated yield and tested chemical content form of polyphenols, alkaloids, flavonoids, saponins, tannins and terpenoids. Yield data analysis was carried out using One Way ANOVA test. The average yield value of katuk leaf extract in the wind-dry drying method was 11.86±0.23%, the sun was 12.26±0.70%, the oven was 13.64±0.74%. One Way ANOVA test showed significant differences in wind and oven drying, sun and oven drying. Phytochemical screening of each drying showed the presence of polyphenols, alkaloids, flavonoids, saponins, tannins and triterpenoids. The conclusion of this study was that the drying method affects the yield of katuk leaf extract but has no effect on chemical content.</p> 2022-09-30T00:00:00+00:00 Copyright (c) 2022 The Author(s) Aktivitas antioksidan ekstrak air daun kelor (Moringa oleifera) dengan metode DPPH serta analisis kualitatif kandungan metabolit sekunder 2022-09-02T03:46:02+00:00 Laili Muna <p>Sunlight contains UV radiation which will have an impact on the skin if exposed continuously and cause premature aging of the skin. The use of cosmetic products that contain antioxidant compounds is needed to avoid premature aging due to exposure to UV rays. Antioxidants used in cosmetics generally come from synthetic compounds, namely BHT (Butyl hydroxytoluene) whose use will have a negative impact on the skin if used in the long term, so in this study, <em>Moringa oleifera </em>leaf was used as a natural antioxidant. The purpose of this study is to determine the antioxidant activity of Moringa leaf water extract by calculating IC<sub>50</sub> and using a comparison standard of vitamin C. The method used in this study is the stratified maceration method with measurement of antioxidant activity using the DPPH method. The results showed that the aqueous extract of Moringa leaves contains secondary metabolites of flavonoids, tannins, saponins, and alkaloids that play a role in antioxidant activity. The test results of Moringa leaf water extract showed moderate antioxidant activity with an IC<sub>50</sub> value of 87.54 ppm, while the comparison control vitamin C obtained an IC<sub>50</sub> of 483.53 ppm. This is because vitamin C has been oxidized so that the ability to donate protons to DPPH free radicals is also reduced.</p> 2022-09-30T00:00:00+00:00 Copyright (c) 2022 The Author(s) Molecular docking study of natural compounds from red betel (Piper crocatum Ruiz & Pav) as inhibitor of secreted aspartic proteinase 5 (Sap 5) in Candida albicans 2022-03-17T09:42:56+00:00 Gusnia Meilin Gholam Iman Akhyar Firdausy <p><em>Candida albicans</em> can cause adverse infections in humans. The targeting of Sap 5 is due to its virulence factor in <em>C. albicans</em>. The method used is molecular docking using YASARA structure and BIOVIA Discovery Studio. The purpose of this study was to investigate the molecular interaction between red betel and Sap 5 as a potential inhibitor of <em>C. albicans</em> in infecting humans. The results showed that CHEMBL216163 (9,644 kcal/mol) and MLS000557666 (9,525 kcal/mol) have Binding energy above Pepstatin (9,484 kcal/mol) and affect the active site of Sap 5 so that the two test ligands could be further analyzed.</p> 2022-09-30T00:00:00+00:00 Copyright (c) 2022 The Author(s) Analisis fitokimia dan kromatografi lapis tipis ekstrak etanol daun rosella (Hibiscus sabdariffa L.) 2022-08-26T01:53:29+00:00 Tira Risa Oktapiya Nofran Putra Pratama Nur'aini Purnamaningsih <p>Rosella (<em>Hibiscus sabdariffa</em> L) is a plant belonging to the Malvaceae family. This plant is widely used as herbal medicine. Rosella leaves have many compounds that can function as antioxidants and antibacterials. As a crude material for traditional medicine, it is necessary to know the content of secondary metabolites contained in rosella leaves both quantitatively and qualitatively as one of the standardization parameters. The objective of this study was to determine the content of secondary metabolites contained in the ethanolic extract of rosella leaves through phytochemical analysis and Thin Layer Chromatography. Rosella leaf extraction was carried out by maceration method using 70% ethanol as solvent. Testing the content of secondary metabolites in the ethanolic extract of rosella leaves was carried out by phytochemical screening. Furthermore, the TLC test was carried out to confirm the presence of a positive group of compounds on phytochemical screening. Phytochemical screening from rosella leaves extract revealed the presence of alkaloids, flavonoids, saponins and tannins. The TLC system used in this study was able to separate the phytochemical content and gave positive results confirming the phytochemical screening results. The eluent used was chloroform:methanol:acetic acid with a ratio of 14:2:1 obtained spots with an Rf of 0.737 which is similar to the Rf standard of quercetin which is 0.762.</p> 2022-09-30T00:00:00+00:00 Copyright (c) 2022 The Author(s) Kecambah: Agen penghidrolisis pati yang potensial 2022-08-28T01:50:29+00:00 Lina Permatasari <p>Starch is a group of complex carbohydrates containing amylose and amylopectin. Starch can be broken down into simpler molecules such as maltose, isomaltose, and glucose which is called the hydrolysis process. Starch hydrolysis is very useful in several food industries. Enzymatic hydrolysis of starch usually uses the amylase enzyme derived from saliva. However, if you are going to carry out the hydrolysis process on a large scale, it requires large amounts of enzymes. Therefore, this study aimed to examine the ability of enzymes in sprouts to hydrolyze starch and compare it with the ability of starch hydrolysis by saliva and HCl. The isolated sprout samples were added to the starch solution and then incubated at 37<sup>o</sup>C. Every 5 minutes the mixture was tested qualitatively with Benedict's test and iodine. The same treatment for saliva and HCL. However, HCl was incubated at 100<sup>o</sup>C. The results of the qualitative test using Benedict's test and the iodine test showed enzymatic process had a higher ability to hydrolyze starch than chemically with HCl. The α-amylase enzyme produced from sprouts showed a higher starch hydrolysis ability than saliva. Sprouts are a natural source that can be developed as a starch hydrolyzing agent.</p> 2022-09-30T00:00:00+00:00 Copyright (c) 2022 The Author(s)