https://jffk.unram.ac.id/index.php/sjp/issue/feedSasambo Journal of Pharmacy2024-09-30T13:14:48+00:00apt. Nisa Isneni Hanifa, M.Sc.[email protected]Open Journal Systems<p align="justify"><strong><a href="http://jffk.unram.ac.id/index.php/sjp/management/settings/context//index.php/ssp/index">Sasambo Journal of Pharmacy </a> (p-ISSN: <a href="http://issn.pdii.lipi.go.id/issn.cgi?daftar&1592614815&1&&2020">2723-2824</a>; e-ISSN: <a href="http://issn.pdii.lipi.go.id/issn.cgi?daftar&1592615312&1&&2020">2723-2832</a>) </strong> is a scientific journal publishing original articles research in pharmaceutical science. The Journal is managed by<strong> <a href="http://farmasi.unram.ac.id/">the Pharmacy Study Program</a>, <a href="http://jffk.unram.ac.id/index.php/sjp/management/settings/context//index.php/ssp/manager/setup/unram.ac.id">Mataram University</a></strong></p>https://jffk.unram.ac.id/index.php/sjp/article/view/364Influence of extraction method on total phenolic content and antioxidant activity of Sappan Wood (Caesalpinia sappan L.) extract 2024-09-02T07:26:20+00:00Tubagus Akmal[email protected]Yenni Puspita Tanjung[email protected]Andi Ika Julianti[email protected]Aulia Gustiani Lestari[email protected]Aljan Aljan[email protected]<p>Sappan wood is a botanical species that contains a high concentration of phenolic compounds, which contribute to several pharmacological properties, including antidiabetic, antibacterial, antioxidant, and wound-healing activities. In order to achieve phenolic compounds of high quality and quantity, it is crucial to select an appropriate extraction procedure. Plant extraction is an important step for chemical isolation, chemical analysis, and evaluating the biological and pharmacological activities of plant compounds. Therefore, determining the most favorable extraction conditions is a critical undertaking in order to maximize both the quantity of active plant compounds and the extraction yield. This research aimed to compare extraction methods based on total phenolic content (TPC) and antioxidant activity (IC<sub>50</sub>). The extraction techniques employed include maceration, stirring-assisted extraction (SAE), ultrasound-assisted extraction (UAE), and microwave-assisted extraction (MAE). The results show TPC values for maceration, SAE, UAE, and MAE, which are 132.85±1.44, 150.99±1.69, 206.70±6.56, and 115.70±1.44 mg GAE/g DE, respectively. The DPPH antioxidant activity (IC<sub>50</sub>) values are 32.33±2.64, 25.01±0.34, 20.68±0.29, and 29.18±0.70 µg/mL, respectively. The research findings indicate that various extraction procedures can impact the extraction yield, total phenolic content (TPC), and antioxidant activity (IC<sub>50</sub>) of sappan wood, and UAE is the best extraction method.</p>2024-09-30T00:00:00+00:00Copyright (c) 2024 The Author(s)https://jffk.unram.ac.id/index.php/sjp/article/view/261Antioksidan in vivo buah beligo (Benincasa hispida (Thunb.) Cogn.) berdasarkan penurunan kadar malondialdehid tikus jantan wistar 2024-09-03T23:22:37+00:00Nur Alim[email protected]Nur Alfiah Irfayanti[email protected]Siti Fajrianti[email protected]Suarni Suarni[email protected]Raudatul Jannah[email protected]<p>The aim is to ascertain the in vivo antioxidant activity of beligo fruit flesh ethanol extract based on the measurement of malondialdehyde levels in Wistar male rats generated by used frying oil. The procedure involves macerating 70% ethanol to extract the flesh from beligo fruit and assessing the in vivo antioxidant activity by measuring the amounts of malondialdehyde in fifty Wistar male rats split into 5 groups. Group V received vitamin C at a dose of 27 mg/kgBW, and groups II, III, and IV received an ethanol extract of beligo fruit flesh at 100, 200, and 400 mg/kg BW. Group I received 1% Na-CMC as a negative control. Using a UV-Vis spectrophotometer, malondialdehyde levels were determined using the TBARS test. Statistical data analysis by a Completely Randomized Design (CRD) and an Honestly Significant Difference (HSD) follow-up test. Malondialdehyde levels decreased in Group I (19.16%), Group II (78.70%), Group III (82.86%), Group IV (87.76%), and Group V (90.23%) according to the study's findings. The study findings demonstrated the antioxidant potential of beligo fruit flesh ethanol extract at doses of 100 mg, 200 mg/kg BW (p<0.05), and 400 mg/kg BW (p<0.01) in lowering malondialdehyde levels in Wistar male rats.</p>2024-09-30T00:00:00+00:00Copyright (c) 2024 The Author(s)https://jffk.unram.ac.id/index.php/sjp/article/view/347Optimasi formula sampo ekstrak etanol daun delima (Punica granatum L.) dengan metode Simplex Lattice Design2024-09-02T07:29:56+00:00Syifaul Jannah[email protected]Wahida Hajrin[email protected]Nisa Isneni Hanifa[email protected]<p>Anti-dandruff shampoo on the market still uses zinc pyriton which has the side effect of causing hair loss. Pomegranate leaves have strong antifungal activity against dandruff-causing fungi. This research aims to determine the optimum formula and physical properties of pomegranate leaf shampoo preparations with variations of SLS and cocamide DEA. The ethanol extract of pomegranate leaves was extracted by soxhletation and carried out in a tube test. Eight shampoo formula designs were determined using the SLD method. The shampoo was tested for foam height, pH, and viscosity to obtain the optimum formula. The optimum shampoo preparation was tested for physical properties, including organoleptic tests, homogeneity, foam stability, foam height, pH, and viscosity. The results of the test for the physical properties of the optimum shampoo preparation were verified using the SPSS application with the one-sample t-test method. Pomegranate leaf ethanol extract positively contains alkaloids, flavonoids, tannins, and saponins. The optimization results obtained the optimum shampoo formula, namely a combination of SLS 5.5% and cocamide DEA 15.5%. Optimum formula shampoo has a black color, menthol odor, gel form, ingredients mixed homogeneously, foam stability 81.83%, foam height 9.30 ± 0.26 cm, pH 5.91 ± 0.45, and viscosity 1646.66 ± 220.23 cP.</p>2024-09-30T00:00:00+00:00Copyright (c) 2024 The Author(s)https://jffk.unram.ac.id/index.php/sjp/article/view/336Profil kadar metabolit sekunder: Steroid, alkaloid, dan tanin ekstrak daun bintangur (Calophyllum soulattri)2024-09-02T06:41:22+00:00Hadi Kurniawan[email protected]Siti Nani Nurbaeti[email protected]Hariyanto IH[email protected]Fajar Nugraha[email protected]Inarah Fajriaty[email protected]<p>Bintangur leaf is one of the potential plants to be developed into a standardized herbal medicine which has many benefits such as antioxidant, anti-inflammatory and antibacterial. The aim of this study is to determine the steroid, tannin, and alkaloids of bintangur leaf extract. Preparation of bintangur leaves was conducted by soxhletation extraction technique with 96% ethanol as solvent. Determination of tannin tannic acid equivalent, and alkaloid quinine equivalent was analyzed by UV-Vis spectrophotometry method. While the analysis of steroid content β-sitosterol equivalent using a TLC Scanner. The results of the analysis showed that steroid content was 11061,49 µgBSE/g, alkaloid was 307,16 µgQE/g, and tannin was 6,586 %w/w TAE.</p>2024-09-30T00:00:00+00:00Copyright (c) 2024 The Author(s)https://jffk.unram.ac.id/index.php/sjp/article/view/245Aktivitas antelmintik ekstrak herba meniran (Phyllanthus niruri) terhadap Paramphistomum spp. 2023-09-29T15:33:00+00:00Baiq Ihda Nanda Safriyana[email protected]Agriana Rosmalina Hidayati[email protected]Iman Surya Pratama[email protected]<p><em>Phyllanthus niruri</em> is traditionally used to treat intestinal worms. The content of flavonoids in <em>Phyllanthus niruri</em> has the potential as an anthelmintic. The aims of study are to identify flavonoid compounds of the ethanolic extract of <em>Phyllanthus niruri</em> and determine the anthelmintic activity against <em>Paramphistomum</em> spp. <em>Paramphistomum</em> spp. grouped into positive control (Albendazole 10% w/v), negative control (CMC-Na 0.5% w/v), ethanolic extract of <em>Phyllanthus niruri</em> 1.25%, 2.5%, and 5% w/v. For 5 hours, the time and quantity of dead worms were counted every 15 minutes. The average time of death and percentage of worm mortality were then calculate. Differences in average time of death were analyzed with <em>Kruskal-Wallis</em> and <em>Mann Whitney</em>. The results of the test tube and TLC showed the content of flavonoid compounds. Percentage of mortality of <em>Paramphistomum </em>spp. obtained by 100%. Average death time of <em>Paramphistomum</em> spp. at 50, 275, 155, 140, and 115 minutes respectively. Ethanolic extract of <em>Phyllanthus niruri</em> contained flavonoid compounds and has anthelmintic activity with an optimum concentration of 5% w/v although lower than Albendazole 10% w/v (p<0.05).</p>2024-09-30T00:00:00+00:00Copyright (c) 2024 The Author(s)https://jffk.unram.ac.id/index.php/sjp/article/view/372Optimasi fase gerak dan analisis kadar natrium benzoat pada beberapa sirup rasa jeruk dengan metode kromatografi cair kinerja tinggi (kckt)2024-09-10T05:23:28+00:00Ainil Fithri Pulungan[email protected]Zhazha Santasa[email protected]<p>With the increasing growth of food and beverages in Indonesia, there has been an increase in the manufacture of soft drinks that use the preservative sodium benzoate, particularly in syrup. The concentration of sodium benzoate in beverages should be monitored, because excessive consumption can emerge various health problems. To obtain maximum analysis results, mobile phase optimization is first carried out, which aims to obtain the optimal type of eluent from several types of mobile phase, then proceed with adjusting the sodium benzoate content in the orange-flavored syrup using the HPLC method to establish whether it fits the standards in line with the BPOM Regulation No. 11 of 2019. After optimizing the mobile phase, the most optimal mobile phase is Methanol Pro HPLC: Aquabidestilata (70:30), because in this comparison the chromatogram gives the best result the peak shape is symmetrical, tailing factor is less than 2 and the retention time is less than 10 minutesBased on the findings of the third sample research, the sodium benzoate content in orange-flavored syrup meets the requirements of BPOM Regulation No. 11 of 2019, namely 600 mg/kg.</p>2024-09-30T00:00:00+00:00Copyright (c) 2024 The Author(s)https://jffk.unram.ac.id/index.php/sjp/article/view/388Analisa mutu tablet ibuprofen generik berlogo dan generik bermerek yang diproduksi industri X di Gresik2024-09-13T08:15:44+00:00Oktavia Noer Hidayah Okta[email protected]Dewi Rahmawati[email protected]Marthy Meliana[email protected]Arianti Jalmav[email protected]Yani Ambari[email protected]<p>Ibuprofen tablets are one of the most widely used antipyretic analgesic drugs for self-medication in pharmacies. According to the Biopharmaceutical Classification System (BCS), Ibuprofen is included in Class II or drugs with low solubility, but high permeability. This study was carried out to determine the physical quality of branded generic and branded generic ibuprofen drugs. This research was carried out by dissolution testing on ibuprofen tablets. The results obtained from the physical quality test met the specified requirements. The dissolution test showed that Q30 had dissolved more than 70%. The conclusion is that the drug meets the requirements and there is no difference between generic drugs with the logo and branded generics.</p>2024-09-30T00:00:00+00:00Copyright (c) 2024 The Author(s)