Sasambo Journal of Pharmacy
https://jffk.unram.ac.id/index.php/sjp
<p align="justify"><strong><a href="http://jffk.unram.ac.id/index.php/sjp/management/settings/context//index.php/ssp/index">Sasambo Journal of Pharmacy </a> (p-ISSN: <a href="http://issn.pdii.lipi.go.id/issn.cgi?daftar&1592614815&1&&2020">2723-2824</a>; e-ISSN: <a href="http://issn.pdii.lipi.go.id/issn.cgi?daftar&1592615312&1&&2020">2723-2832</a>) </strong> is a scientific journal publishing original articles research in pharmaceutical science. The Journal is managed by<strong> <a href="http://farmasi.unram.ac.id/">the Pharmacy Study Program</a>, <a href="http://jffk.unram.ac.id/index.php/sjp/management/settings/context//index.php/ssp/manager/setup/unram.ac.id">Mataram University</a></strong></p>Universitas Mataramen-USSasambo Journal of Pharmacy2723-2824<p>Authors who publish with Sasambo Journal of Pharmacy (SJP), agree to the following terms:<br /><br /></p><ol><li>Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a <a href="http://creativecommons.org/licenses/by/4.0/" rel="license">Lisensi Creative Commons Atribusi 4.0 Internasional</a>. This license allows authors to use all articles, data sets, graphics and appendices in data mining applications, search engines, web sites, blogs, and other platforms by providing an appropriate reference. The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.</li><li>Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Sasambo Journal of Pharmacy</li><li>Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See <a href="http://opcit.eprints.org/oacitation-biblio.html">The Effect of Open Access</a>).</li></ol>Influence of extraction method on total phenolic content and antioxidant activity of Sappan Wood (Caesalpinia sappan L.) extract
https://jffk.unram.ac.id/index.php/sjp/article/view/364
<p>Sappan wood is a botanical species that contains a high concentration of phenolic compounds, which contribute to several pharmacological properties, including antidiabetic, antibacterial, antioxidant, and wound-healing activities. In order to achieve phenolic compounds of high quality and quantity, it is crucial to select an appropriate extraction procedure. Plant extraction is an important step for chemical isolation, chemical analysis, and evaluating the biological and pharmacological activities of plant compounds. Therefore, determining the most favorable extraction conditions is a critical undertaking in order to maximize both the quantity of active plant compounds and the extraction yield. This research aimed to compare extraction methods based on total phenolic content (TPC) and antioxidant activity (IC<sub>50</sub>). The extraction techniques employed include maceration, stirring-assisted extraction (SAE), ultrasound-assisted extraction (UAE), and microwave-assisted extraction (MAE). The results show TPC values for maceration, SAE, UAE, and MAE, which are 132.85±1.44, 150.99±1.69, 206.70±6.56, and 115.70±1.44 mg GAE/g DE, respectively. The DPPH antioxidant activity (IC<sub>50</sub>) values are 32.33±2.64, 25.01±0.34, 20.68±0.29, and 29.18±0.70 µg/mL, respectively. The research findings indicate that various extraction procedures can impact the extraction yield, total phenolic content (TPC), and antioxidant activity (IC<sub>50</sub>) of sappan wood, and UAE is the best extraction method.</p>Tubagus AkmalYenni Puspita TanjungAndi Ika JuliantiAulia Gustiani LestariAljan Aljan
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2024-09-302024-09-3052556210.29303/sjp.v5i2.364Antioksidan in vivo buah beligo (Benincasa hispida (Thunb.) Cogn.) berdasarkan penurunan kadar malondialdehid tikus jantan wistar
https://jffk.unram.ac.id/index.php/sjp/article/view/261
<p>The aim is to ascertain the in vivo antioxidant activity of beligo fruit flesh ethanol extract based on the measurement of malondialdehyde levels in Wistar male rats generated by used frying oil. The procedure involves macerating 70% ethanol to extract the flesh from beligo fruit and assessing the in vivo antioxidant activity by measuring the amounts of malondialdehyde in fifty Wistar male rats split into 5 groups. Group V received vitamin C at a dose of 27 mg/kgBW, and groups II, III, and IV received an ethanol extract of beligo fruit flesh at 100, 200, and 400 mg/kg BW. Group I received 1% Na-CMC as a negative control. Using a UV-Vis spectrophotometer, malondialdehyde levels were determined using the TBARS test. Statistical data analysis by a Completely Randomized Design (CRD) and an Honestly Significant Difference (HSD) follow-up test. Malondialdehyde levels decreased in Group I (19.16%), Group II (78.70%), Group III (82.86%), Group IV (87.76%), and Group V (90.23%) according to the study's findings. The study findings demonstrated the antioxidant potential of beligo fruit flesh ethanol extract at doses of 100 mg, 200 mg/kg BW (p<0.05), and 400 mg/kg BW (p<0.01) in lowering malondialdehyde levels in Wistar male rats.</p>Nur AlimNur Alfiah IrfayantiSiti FajriantiSuarni SuarniRaudatul Jannah
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2024-09-302024-09-3052637010.29303/sjp.v5i2.261Optimasi formula sampo ekstrak etanol daun delima (Punica granatum L.) dengan metode Simplex Lattice Design
https://jffk.unram.ac.id/index.php/sjp/article/view/347
<p>Anti-dandruff shampoo on the market still uses zinc pyriton which has the side effect of causing hair loss. Pomegranate leaves have strong antifungal activity against dandruff-causing fungi. This research aims to determine the optimum formula and physical properties of pomegranate leaf shampoo preparations with variations of SLS and cocamide DEA. The ethanol extract of pomegranate leaves was extracted by soxhletation and carried out in a tube test. Eight shampoo formula designs were determined using the SLD method. The shampoo was tested for foam height, pH, and viscosity to obtain the optimum formula. The optimum shampoo preparation was tested for physical properties, including organoleptic tests, homogeneity, foam stability, foam height, pH, and viscosity. The results of the test for the physical properties of the optimum shampoo preparation were verified using the SPSS application with the one-sample t-test method. Pomegranate leaf ethanol extract positively contains alkaloids, flavonoids, tannins, and saponins. The optimization results obtained the optimum shampoo formula, namely a combination of SLS 5.5% and cocamide DEA 15.5%. Optimum formula shampoo has a black color, menthol odor, gel form, ingredients mixed homogeneously, foam stability 81.83%, foam height 9.30 ± 0.26 cm, pH 5.91 ± 0.45, and viscosity 1646.66 ± 220.23 cP.</p>Syifaul JannahWahida HajrinNisa Isneni Hanifa
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2024-09-302024-09-3052718210.29303/sjp.v5i2.347Profil kadar metabolit sekunder: Steroid, alkaloid, dan tanin ekstrak daun bintangur (Calophyllum soulattri)
https://jffk.unram.ac.id/index.php/sjp/article/view/336
<p>Bintangur leaf is one of the potential plants to be developed into a standardized herbal medicine which has many benefits such as antioxidant, anti-inflammatory and antibacterial. The aim of this study is to determine the steroid, tannin, and alkaloids of bintangur leaf extract. Preparation of bintangur leaves was conducted by soxhletation extraction technique with 96% ethanol as solvent. Determination of tannin tannic acid equivalent, and alkaloid quinine equivalent was analyzed by UV-Vis spectrophotometry method. While the analysis of steroid content β-sitosterol equivalent using a TLC Scanner. The results of the analysis showed that steroid content was 11061,49 µgBSE/g, alkaloid was 307,16 µgQE/g, and tannin was 6,586 %w/w TAE.</p>Hadi KurniawanSiti Nani NurbaetiHariyanto IHFajar NugrahaInarah Fajriaty
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2024-09-302024-09-3052839010.29303/sjp.v5i2.336Aktivitas antelmintik ekstrak herba meniran (Phyllanthus niruri) terhadap Paramphistomum spp.
https://jffk.unram.ac.id/index.php/sjp/article/view/245
<p><em>Phyllanthus niruri</em> is traditionally used to treat intestinal worms. The content of flavonoids in <em>Phyllanthus niruri</em> has the potential as an anthelmintic. The aims of study are to identify flavonoid compounds of the ethanolic extract of <em>Phyllanthus niruri</em> and determine the anthelmintic activity against <em>Paramphistomum</em> spp. <em>Paramphistomum</em> spp. grouped into positive control (Albendazole 10% w/v), negative control (CMC-Na 0.5% w/v), ethanolic extract of <em>Phyllanthus niruri</em> 1.25%, 2.5%, and 5% w/v. For 5 hours, the time and quantity of dead worms were counted every 15 minutes. The average time of death and percentage of worm mortality were then calculate. Differences in average time of death were analyzed with <em>Kruskal-Wallis</em> and <em>Mann Whitney</em>. The results of the test tube and TLC showed the content of flavonoid compounds. Percentage of mortality of <em>Paramphistomum </em>spp. obtained by 100%. Average death time of <em>Paramphistomum</em> spp. at 50, 275, 155, 140, and 115 minutes respectively. Ethanolic extract of <em>Phyllanthus niruri</em> contained flavonoid compounds and has anthelmintic activity with an optimum concentration of 5% w/v although lower than Albendazole 10% w/v (p<0.05).</p>Baiq Ihda Nanda SafriyanaAgriana Rosmalina HidayatiIman Surya Pratama
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2024-09-302024-09-3052919610.29303/sjp.v5i2.245Optimasi fase gerak dan analisis kadar natrium benzoat pada beberapa sirup rasa jeruk dengan metode kromatografi cair kinerja tinggi (kckt)
https://jffk.unram.ac.id/index.php/sjp/article/view/372
<p>With the increasing growth of food and beverages in Indonesia, there has been an increase in the manufacture of soft drinks that use the preservative sodium benzoate, particularly in syrup. The concentration of sodium benzoate in beverages should be monitored, because excessive consumption can emerge various health problems. To obtain maximum analysis results, mobile phase optimization is first carried out, which aims to obtain the optimal type of eluent from several types of mobile phase, then proceed with adjusting the sodium benzoate content in the orange-flavored syrup using the HPLC method to establish whether it fits the standards in line with the BPOM Regulation No. 11 of 2019. After optimizing the mobile phase, the most optimal mobile phase is Methanol Pro HPLC: Aquabidestilata (70:30), because in this comparison the chromatogram gives the best result the peak shape is symmetrical, tailing factor is less than 2 and the retention time is less than 10 minutesBased on the findings of the third sample research, the sodium benzoate content in orange-flavored syrup meets the requirements of BPOM Regulation No. 11 of 2019, namely 600 mg/kg.</p>Ainil Fithri PulunganZhazha Santasa
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2024-09-302024-09-30529710010.29303/sjp.v5i2.372Analisa mutu tablet ibuprofen generik berlogo dan generik bermerek yang diproduksi industri X di Gresik
https://jffk.unram.ac.id/index.php/sjp/article/view/388
<p>Ibuprofen tablets are one of the most widely used antipyretic analgesic drugs for self-medication in pharmacies. According to the Biopharmaceutical Classification System (BCS), Ibuprofen is included in Class II or drugs with low solubility, but high permeability. This study was carried out to determine the physical quality of branded generic and branded generic ibuprofen drugs. This research was carried out by dissolution testing on ibuprofen tablets. The results obtained from the physical quality test met the specified requirements. The dissolution test showed that Q30 had dissolved more than 70%. The conclusion is that the drug meets the requirements and there is no difference between generic drugs with the logo and branded generics.</p>Oktavia Noer Hidayah OktaDewi RahmawatiMarthy MelianaArianti JalmavYani Ambari
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2024-09-302024-09-305210110810.29303/sjp.v5i2.388