Potensi anti-kanker payudara tanaman songga (Strychnos lucida R.Br): Tinjauan interaksi molekuler terhadap reseptor estrogen-α in silico

Muhammad Andre Reynaldi; Arif Setiawansyah

doi:10.29303/sjp.v3i1.149

Potensi anti-kanker payudara tanaman songga (Strychnos lucida R.Br): Tinjauan interaksi molekuler terhadap reseptor estrogen-α in silico

Penulis

Muhammad Andre Reynaldi , Arif Setiawansyah

DOI:

10.29303/sjp.v3i1.149

Diterbitkan:

2022-04-28

Terbitan:

Vol 3 No 1 (2022): April

Kata Kunci:

Songga, Strychnos lucida, breast cancer, estrogen receptor-α

Articles

##submission.downloads##

PDF (English)

Cara Mengutip

Reynaldi, M. A., & Setiawansyah, A. (2022). Potensi anti-kanker payudara tanaman songga (Strychnos lucida R.Br): Tinjauan interaksi molekuler terhadap reseptor estrogen-α in silico. Sasambo Journal of Pharmacy, 3(1), 30–35. https://doi.org/10.29303/sjp.v3i1.149

Unduh Sitasi

Abstrak

Songga (Styrchnos lucida R.Br) is a plant that has potential to be developed as an anti-breast cancer against. This study was conducted to predict the secondary metabolite derived from songga, which potential as anti-breast cancer through inhibition of estrogen receptor-α. A molecular docking study was carried out using Autodock Vina assisted by AutodockTool and Biovia Discovery Studio. The study used estrogen receptor-α as a protein and ten compounds from songga as ligands. The 3D structure of estrogen receptor-α and ten ligands were obtained from Protein Data Bank and the PubChem database. The result revealed that strychnine N-oxide is the compound that has the lowest free binding energy and inhibition constant with the value 9.6 kcal/mol and 0.09 µM, respectively. This indicated that strychnine N-oxide has an excellent affinity for estrogen receptor-α. Thus, this compound is predicted to inhibit the estrogen receptor-α and can be developed as anti-breast cancer. However, further investigations such as molecular dynamics simulation, in vitro and in vivo assays should be undertaken.

Referensi

Afriza, D., Suriyah, W. H., & Ichwan, S. J. A. (2018). In silico analysis of molecular interactions between the anti-apoptotic protein survivin and dentatin, nordentatin, and quercetin. Journal of Physics: Conference Series, 1073(3). https://doi.org/10.1088/1742-6596/1073/3/032001

Bai, Z., & Gust, R. (2009). Breast cancer, estrogen receptor and ligands. Archiv Der Pharmazie, 342(3), 133–149. https://doi.org/10.1002/ardp.200800174

Brooks, B. R., Brooks, C. L. 3rd, Mackerell, A. D. J., Nilsson, L., Petrella, R. J., Roux, B., Won, Y., Archontis, G., Bartels, C., Boresch, S., Caflisch, A., Caves, L., Cui, Q., Dinner, A. R., Feig, M., Fischer, S., Gao, J., Hodoscek, M., Im, W., … Karplus, M. (2009). CHARMM: the biomolecular simulation program. Journal of Computational Chemistry, 30(10), 1545–1614. https://doi.org/10.1002/jcc.21287

Busonero, C., Leone, S., & Acconcia, F. (2017). Emetine induces estrogen receptor alpha degradation and prevents 17β-estradiol-induced breast cancer cell proliferation. In Cellular oncology (Dordrecht) (Vol. 40, Issue 3, pp. 299–301). https://doi.org/10.1007/s13402-017-0322-z

Cazzaniga, M., & Bonanni, B. (2012). Breast cancer chemoprevention: old and new approaches. Journal of Biomedicine & Biotechnology, 2012, 985620. https://doi.org/10.1155/2012/985620

Ciruelos, E., Pascual, T., Arroyo Vozmediano, M. L., Blanco, M., Manso, L., Parrilla, L., Muñoz, C., Vega, E., Calderón, M. J., Sancho, B., & Cortes-Funes, H. (2014). The therapeutic role of fulvestrant in the management of patients with hormone receptor-positive breast cancer. Breast (Edinburgh, Scotland), 23(3), 201–208. https://doi.org/10.1016/j.breast.2014.01.016

Eroles, P., Bosch, A., Pérez-Fidalgo, J. A., & Lluch, A. (2012). Molecular biology in breast cancer: intrinsic subtypes and signaling pathways. Cancer Treatment Reviews, 38(6), 698–707. https://doi.org/10.1016/j.ctrv.2011.11.005

Itoh, A., Tanaka, Æ. Y., & Nagakura, Æ. N. (2006). A quinic acid ester from Strychnos lucida. 146–148. https://doi.org/10.1007/s11418-005-0021-3

Jemal, A., Bray, F., & Ferlay, J. (2011). Global Cancer Statistics: 2011. CA Cancer J Clin, 49(2), 1,33-64. https://doi.org/10.3322/caac.20107.Available

Ko, E.-Y., & Moon, A. (2015). Natural Products for Chemoprevention of Breast Cancer. Journal of Cancer Prevention, 20(4), 223–231. https://doi.org/10.15430/JCP.2015.20.4.223

Leon-Ferre, R. A., Polley, M.-Y., Liu, H., Gilbert, J. A., Cafourek, V., Hillman, D. W., Elkhanany, A., Akinhanmi, M., Lilyquist, J., Thomas, A., Negron, V., Boughey, J. C., Liu, M. C., Ingle, J. N., Kalari, K. R., Couch, F. J., Visscher, D. W., & Goetz, M. P. (2018). Impact of histopathology, tumor-infiltrating lymphocytes, and adjuvant chemotherapy on prognosis of triple-negative breast cancer. Breast Cancer Research and Treatment, 167(1), 89–99. https://doi.org/10.1007/s10549-017-4499-7

Lipinski, C. A. (2004). Lead- and drug-like compounds: the rule-of-five revolution. Drug Discovery Today: Technologies, 1(4), 337–341 https://doi.org/https://doi.org/10.1016/j.ddtec.2004.11.007

Manurung, H., Sari, R. K., Syafii, W., Cahyaningsih, U., & Ekasari, W. (2019). Antimalarial activity and phytochemical profile of ethanolic and aqueous extracts of bidara laut (Strychnos ligustrina Blum) wood. Journal of the Korean Wood Science and Technology, 47(5), 587–596. https://doi.org/10.5658/WOOD.2019.47.5.587

Matsuo, K., Shimada, M., Yamaguchi, S., Kanao, H., Nakanishi, T., Saito, T., Kamiura, S., Iwata, T., Mikami, M., & Sugiyama, T. (2018). Identifying a candidate population for ovarian conservation in young women with clinical stage IB–IIB cervical cancer. International Journal of Cancer, 142(5), 1022–1032. https://doi.org/10.1002/ijc.31084

Morris, G. M., Huey, R., Lindstrom, W., Sanner, M. F., Belew, R. K., Goodsell, D. S., & Olson, A. J. (2009). AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Journal of Computational Chemistry, 30(16), 2785–2791. https://doi.org/10.1002/jcc.21256

Muttaqin, F. Z., Kharisma, D., Asnawi, A., & Kurniawan, F. (2020). Pharmacophore and Molecular Docking-Based Virtual Screening of B-Cell Lymphoma 2 (BCL 2) Inhibitor from Zinc Natural Database as Anti-Small Cell Lung Cancer. 10(2), 143–147.

Paterni, I., Granchi, C., Katzenellenbogen, J. A., & Minutolo, F. (2014). Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential. Steroids, 90, 13–29. https://doi.org/10.1016/j.steroids.2014.06.012

Russo, J., & Russo, I. H. (2006). The role of estrogen in the initiation of breast cancer. Journal of Steroid Biochemistry and Molecular Biology, 102(1-5 SPEC. ISS.), 89–96. https://doi.org/10.1016/j.jsbmb.2006.09.004

Sarmento, N. da C., Worachartcheewan, A., Pingaew, R., Prachayasittikul, S., Ruchirawat, S., & Prachayasittikul, V. (2015). Antimicrobial, antioxidant and anticancer activities of Strychnos lucida R. Br. African Journal of Traditional, Complementary and Alternative Medicines, 12(4), 122–127. https://doi.org/10.4314/ajtcam.v12i4.18

Setiawan, O., & Rostiwati, T. (2014). Bidara Laut (Strychnos ligustrina Blume. syn. S. lucida R. Br): HHBK Potensial di NTB dan Bali. In Bogor: Forda Press.

Trott, O. & Olson, A.J. (2010). AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading, Journal of Computational Chemistry 31, 455-461.

Waks, A. G., & Winer, E. P. (2019). Breast Cancer Treatment: A Review. JAMA, 321(3), 288–300. https://doi.org/10.1001/jama.2018.19323

Biografi Penulis

Muhammad Andre Reynaldi, Department of Pharmaceutical Chemistry, School of Pharmacy, Bandung Institute of Technology, Indonesia

Master Student of Pharmaceutical Science, Department of Pharmaceutical Chemistry, School of Pharmacy, Bandung Institute of Technology

Lisensi

Artikel ini berlisensi Creative Commons Attribution 4.0 International License.

Authors who publish with Sasambo Journal of Pharmacy (SJP), agree to the following terms:

Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Lisensi Creative Commons Atribusi 4.0 Internasional. This license allows authors to use all articles, data sets, graphics and appendices in data mining applications, search engines, web sites, blogs, and other platforms by providing an appropriate reference. The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Sasambo Journal of Pharmacy
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

Potensi anti-kanker payudara tanaman songga (Strychnos lucida R.Br): Tinjauan interaksi molekuler terhadap reseptor estrogen-α in silico

Penulis

DOI:

Diterbitkan:

Terbitan:

Kata Kunci:

Articles

##submission.downloads##

Cara Mengutip

Abstrak

Referensi

Biografi Penulis

Muhammad Andre Reynaldi, Department of Pharmaceutical Chemistry, School of Pharmacy, Bandung Institute of Technology, Indonesia

Lisensi

Terbitan Terkini

Informasi

Dikembangkan Oleh

Official Website Of

Jurnal Farmasi, Fakultas Kedokteran, Universitas Mataram

Contact Us

Official link

Share & Follow