Antibacterial Activities from Gel Hand Sanitizer of Jatropha curcas Leaves Ethanolic Extract Against Staphylococcus aures ATCC 25923
Penulis
Erviana Vernanda Margaretha , Yohanes Juliantoni , Dyke Gita WirasisyaDOI:
10.29303/sjp.v1i1.8Diterbitkan:
2020-04-30Terbitan:
Vol 1 No 1 (2020): AprilArticles
##submission.downloads##
Cara Mengutip
Abstrak
Food borne disease is a disease with symptoms such as nausea, diarrhea and vomiting. The main cause of FBD was food contamination of Staphylococcus aureus. Jarak pagar (Jatropha curcas Linn) leave is a plant that have antibacterial activity against S. aureus because it contains saponin, flavonoid, and tannin. This research aimed to determine the antibacterial activity of the ethanolic extract of Jatropha curcas Linn. leaves, formulated them as gel hand sanitizer, and evaluated the antibacterial activity of the formula. The sample was collected, determined, and extracted with ethanol 70% using maceration, and the phytochemical screening conducted to the concentrate extract. The antibacterial activity test conducted by well diffusion method with concetration 50, 100, dan 150 mg/mL. Then the effective extract group has formulated to gel hand sanitizer. The gel hand sanitizer formula tested the antibacterial activity and physical properties by organoleptic, pH, stability, and spreadablility. The result showed that the extract with concentration 50, 100, dan 150 mg/mL has inhibition zone diameter was 9.9, 15.7, and 16.4 mm, respectively. The gel hand sanitizer of Jatropha curcas Linn extract was formulated by using 100 mg/mL concentration of extract. The gel was physically stable and had inhibition zone diameter was 15.6 mmReferensi
Addis, M., & Desta, S. (2015). A Review on Major Food Borne Bacterial Illnesses. Journal of Tropical Diseases. 3(4).
Argudin, M.A., Maria, C. M., & Maria, R.R. (2010). Food Poisoning and Staphylococcus aureus Enterotoxins. Toxins. 2, 1752.
Arisanti, R.R., Citra, I., & Siswanto, A.W. (2018). Kontribusi Agen dan Faktor Penyebab Kejadian Luar Biasa Keracunan Pangan di Indonesia: Kajian Sistematis. Berita Kedokteran Masyarakat Journal of Community Medicine and Public Health. 34(3) ,100.
Dahlan, M.S. (2001). Statistik untuk Kedokteran dan Kesehatan: Deskriptif, Bivariat, dan Multivariat, Dilengkapi Aplikasi dengan Menggunakan SPSS Edisi 5. Jakarta: Salemba Medika.
Farhadi, F., Bahman K., Mehrdad I., & Milad I. (2018). Antibacterial Activity of Flavonoids and Their Structure- Activity Relationship: An Update Review. Phytotherapy Research. 33.
Galvez, M. A. C. (2016). Antibacterial Activity and Phytochemical Screening of Selected Folkloric Medicinal Plants of Manggok, Hungduan, Ifungao, Cordillera Administrative Region, Philippines. International Journal of Scientific and Research Publications. 6(1).
Jeongsoon, K., & Kim, M. (2017). Study on the Infection of Staphylococcus aureus and Diagnostic Methods in Food. Staph Infection. Juliantoni, Y. & Dyke G. W. 2018. Optimasi Formula Obat Kumur Ekstrak Herba Ashitaba (Angelica keiskei) Sebagai Antibakteri Karies Gigi. Kartika: Jurnal Ilmiah Farmasi. 6(1).
Kadariya, J., Tara, C. S., & Dipendra, T. (2014). Staphylococcus aureus and Staphylococcal Food-Borne Disease: An Ongoing Challenge in Public Health. BioMed Research International. Mailoa, M. N., Meta M., & Natsir D. (2014). Test of Antimicrobial Activity of Tannins Extract from Guava Leaves to Pathogens Microbial. The International Asian Research Journal. 2(1).
Manus, N., Paulina, V.Y.Y, & Novel, S. K. (2016). Formulasi Sediaan Gel Minyak Atsiri Daun Sereh (Cymbopogon Citratus) Sebagai Antiseptik Tangan. PHARMACON. 5(3).
Mutiatikum, D.V. (2010) Standardisasi Simplisia dari Buah Miana (Plectranthus seutellariodes [L] R.Bth) yang berasal dari 3 tempat tumbuh Manado, Kupang, dan Papua. Buletin Penelitian Kesehatan. Volume 38 No.1 : 1-16
Naibaho, D.H., Yamkan, V.Y., Weni, & Wiyono. (2013). Pengaruh Basis Salep Terhadap Formulasi Sediaan Salep Ekstrak Daun Kemangi (Ocinum sanchum L.) pada Kulit Punggung Kelinci yang dibuat Infeksi Staphylococcus aureus, Jurnal ilmiah Farmasi – UNSRAT, 2(2).
Nuria, M.C., Arvin, F., & Sumantri. (2009). Uji Aktivitas Antibakteri Ekstrak Etanol Daun Jarak Pagar (Jatropha curcas L) terhadap Bakteri Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, dan Salmonella thypi ATCC 1408. MEDIARGO. 5(2).
Oktaviasari, L. & Abdul, K.Z. 2017. Formulasi dan Uji Stabilitas Fisik Sediaan Lotion O/W Pati Kentang (Solanum Tuberosum L.) Serta Aktivitasnya Sebagai Tabir Surya.
Majalah Farmaseutik. 13(1), 9 – 27. Oyama, M.O., Malachi, O.I., & Oladejo, A.A. (2016). Phytochemical Screening and Antimicrobial Activity of Leaf Extract of Jatropha curcas. Journal of Advances in Medical and Pharmaceutical Sciences. 8(1), 1-6.
Pickering, A.J., Jennifer, D., Annalise, G.B., Jenna, S., Beryl, O., George, O., Robert F.B., & Pavani, K.R. (2013). Access to Waterless Hand Sanitizer Improves Student Hand Hygiene Behavior in Primary Schools in Nairobi, Kenya. American Journal Tropical Medicine Hyiene. 89(3), 411-418.
Rini, E.P., & Estu, R.N., 2018. Uji Daya Hambat Berbagai Merek Hand Sanitizer Gel terhadap Pertumbuhan Bakteri Escherichia coli dan Staphyloccocus aureus. Journal of Pharmaceutical Science and Clinical Research. 1, 21-26.
Sukawaty, Y., Anita A., & Husnul W. (2017). Formula dan Evaluasi Gel Pembersih Tangan Ekstrak Bawang Tiwai (Eleutherine bulbosa (Mill.)Urb).
JurnalIlmiah Manuntung.3(1). Taylor, T.A., & Unakal, C.G. (2018). Staphylococcus Aureus. Treasure Island FL : Stat Pearls Publishing. Valgas, C., Simone M. S., Elza F. A. S., & Artur S. J. (2007). Screening Methods To Determine Antibacterial Activity of Natural Products. Brazillian Journal of Microbiology. 38.
Lisensi
Authors who publish with Sasambo Journal of Pharmacy (SJP), agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Lisensi Creative Commons Atribusi 4.0 Internasional. This license allows authors to use all articles, data sets, graphics and appendices in data mining applications, search engines, web sites, blogs, and other platforms by providing an appropriate reference. The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Sasambo Journal of Pharmacy
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
